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Filtering by: Creator Zheng, Ce Remove constraint Creator: Zheng, Ce Creator Bisson, William H. Remove constraint Creator: Bisson, William H.

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BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid.pdf

Creator:

Jiang, Changtao, Xie, Cen, Lv, Ying, Bisson, William H., and et al.

Abstract:

The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...

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ig ly ce rid es (m g pe r g of li ve r) 0 2 4 6 0 20 40 60 Time after treatment
BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid.pdf

Creator:

Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shik Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.

Abstract:

The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...

Full Text:

) ** Vehicle 0 100 200 300 400 ** H ep at ic tr ig ly ce rid es (m g pe r g of li ve r) 0
BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf

Creator:

Engström, Willhelm, Darbre, Philippa, Eriksson, Staffan, Bisson, William H., and et al.

Abstract:

The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells...
The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

Creator:

Ochieng, Josiah, Nangami, Gladys N., Ogunkua, Olugbemiga, Miousse, Isabelle R., Koturbash, Igor, Odero-Marah, Valerie, McCawley, Lisa J., Nangia-Makker, Pratima, Ahmed, Nuzhat, Luqmani, Yunus, Chen, Zhenbang, Papagerakis, Silvana, Wolf, Gregory T., Dong, Chenfang, Zhou, Binhua P., Brown, Dustin G., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Amedei, Amedeo, Al-Temaimi, Rabeah, Al-Mulla, Fahd, Bisson, William H., and Eltom, Sakina E.

Abstract:

The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of lowdose environmental mixtures and carcinogens in the promotion of invasion and metastasis...

Resource Type:

Article
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Creator:

Narayanan, Kannan Badri, Ali, Manaf, Barclay, Barry J., Bisson, William H., Cheng, Qiang, D'Abronzo, Leandro, Dornetshuber-Fleiss, Rita, Gosh, Paramita M., Gonalez-Guzman, Michael J., Lee, Tae-Jin, Leung, Po Sing, Li, Lin, Luanpitpong, Suidjit, Ratoviski, Edward, Rojanasakul, Yon, Romano, Maria Fiammetta, Romano, Simona, Sinha, Kumar Ranjeet, Yedjou, Clement, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Ryan, Elizabeth P., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Salem, Hosni K., Woodrick, Jordan, Scovassi, Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Kim, Seo Yun, Lowe, Leroy, and Park, Hyun Ho

Abstract:

Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...

Resource Type:

Article

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Academic Affiliation

Environmental and Molecular Toxicology1

Creator

Bisson, William H.[remove]5
Al Mulla, Fahd2
Al Temaimi, Rabeah2
Amedei, Amedeo2
Brown, Dustin G.2
more Creators »

Date

20152

Decade

2010-20192

Language

English [eng]2

Peer Reviewed

Yes2

Resource Type

Article2

Rights Statement

In Copyright3
Copyright Not Evaluated2

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