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Evidence that the Potyvirus P1 Proteinase Functions in trans as an Accessory Factor for Genome Amplification

Creator:

Verchot, Jeanmarie and Carrington, James C.

Abstract:

The tobacco etch potyvirus (TEV) polyprotein is proteolytically processed by three viral proteinases (NIa, HC-Pro, and P1). While the NIa and HC-Pro proteinases each provide multiple functions essential for viral infectivity, the role of the P1 proteinase beyond its autoproteolytic activity is understood poorly. To determine if P1 is necessary...

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Functions in trans as an Accessory Factor for Genome Amplification JEANMARIE VERCHOT AND JAMES C
Debilitation of Plant Potyvirus Infectivity by P1 Proteinase-Inactivating Mutations and Restoration by Second-Site Modifications

Creator:

Verchot, Jeanmarie and Carrington, James C.

Abstract:

Tobacco etch virus (TEV) encodes three proteinases that catalyze processing of the genome-encoded polyprotein. The P1 proteinase originates from the N terminus of the polyprotein and catalyzes proteolysis between itself and the helper component proteinase (HC-Pro). Mutations resulting in substitution of a single amino acid, small insertions, or deletions were...

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Article

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Infectivity by P1 Proteinase-Inactivating Mutations and Restoration by Second-Site Modifications JEANMARIE