Index Catalog // ScholarsArchive@OSU

Creator:: Blake, Matthew R., Holbrook, Scott D., Kotwica-Rolinska, Joanna, Chow, Eileen S., Kretzschmar, Doris, and Giebultowicz, Jadwiga M.
Abstract:: Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a fundamental role in AD pathogenesis. One of the detrimental...
Resource Type:: Article

Creator:: Egenriether, Sada M., Chow, Eileen S., Krauth, Nathalie, and Giebultowicz, Jadwiga M.
Abstract:: Adequate energy stores are essential for survival, and sophisticated neuroendocrine mechanisms evolved to stimulate foraging in response to nutrient deprivation. Food search behavior is usually investigated in young animals, and it is not known how aging alters this behavior. To address this question in Drosophila melanogaster, we compared the ability...
Resource Type:: Article

Creator:: Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...
Resource Type:: Article

Creator:: Krishnan, Natraj, Rakshit, Kuntol, Chow, Eileen S., Wentzell, Jill S., Kretzschmar, Doris, and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological diseases; however, it is not clear whether loss of rhythms is the cause or...
Resource Type:: Article

ScholarsArchive@OSU