Index Catalog // ScholarsArchive@OSU

The kinetochore interaction network (KIN) of ascomycetes

Creator:: Freitag, Michael
Abstract:: Chromosome segregation relies on coordinated activity of a large assembly of proteins, the kinetochore interaction network (KIN). How conserved the underlying mechanisms driving the epigenetic phenomenon of centromere and kinetochore assembly and maintenance are remains unclear, even though various eukaryotic models have been studied. More than 50 different proteins, many...
Resource Type:: Article

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Creator:: Wang, Yizhou, Smith, Kristina M., Taylor, John W., Freitag, Michael, and Stajich, Jason E.
Abstract:: Genome defense likely evolved to curtail the spread of transposable elements and invading viruses. A combination of effective defense mechanisms has been shown to limit colonization of the Neurospora crassa genome by transposable elements. A novel DNA transposon named Sly1-1 was discovered in the genome of the most widely used...
Resource Type:: Article

Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes

Creator:: Schotanus, Klaas, Soyer, Jessica L., Connolly, Lanelle R., Grandaubert, Jonathan, Happel, Petra, Smith, Kristina M., Freitag, Michael, and Stukenbrock, Eva H.
Abstract:: Background: Supernumerary chromosomes have been found in many organisms. In fungi, these “accessory” or “dispensable” chromosomes are present at different frequencies in populations and are usually characterized by higher repetitive DNA content and lower gene density when compared to the core chromosomes. In the reference strain of the wheat pathogen,...
Resource Type:: Article

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

Creator:: Roquis, David, Lepesant, Julie M. J., Picard, Marion A. L., Freitag, Michael, Parrinello, Hugues, Groth, Marco, Emans, Rémi, Cosseau, Céline, and Grunau, Christoph
Abstract:: Background: Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrate embryonic stem cells (ESC). It allows them to rapidly engage specific developmental pathways. We reasoned that non-vertebrate metazoans that encounter a...
Resource Type:: Article

Genome‐wide identification of target genes of a mating‐type α‐domain transcription factor reveals functions beyond sexual development

Creator:: Becker, Kordula, Beer, Christina, Freitag, Michael, and Kück, Ulrich
Abstract:: Penicillium chrysogenum is the main industrial producer of the β-lactam antibiotic penicillin, the most commonly used drug in the treatment of bacterial infections. Recently, a functional MAT1-1 locus encoding the α-box transcription factor MAT1-1-1 was discovered to control sexual development in P. chrysogenum. As only little was known from any organism...
Resource Type:: Article

Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function

Creator:: He, Yue, Yam, Candice, Pomraning, Kyle, Chin, Jacqueline S. R., Yew, Joanne Y., Freitag, Michael, and Oliferenko, Snezhana
Abstract:: Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in specialized cellular organelles, called lipid droplets. Understanding what determines the cellular amount of neutral lipids and their packaging into lipid droplets is of fundamental and applied interest. Using two species of fission yeast, we show that cycling...
Resource Type:: Article

Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential

Creator:: Hurley, Jennifer M., Dasgupta, Arko, Emerson, Jillian M., Smith, Kristina M., Freitag, Michael, Zhou, Xiaoying, Ringelberg, Carol S., Knabe, Nicole, Lipzen, Anna, Linduist, Erika A., Daum, Christopher G., Barry, Kerrie W., Grigoriev, Igor V., Galagan, James E., Bell-Pederson, Deborah, Cheng, Chao, Loros, Jennifer J., and Dunlap, Jay C.
Abstract:: Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic fungal and animal clocks comprise transcription-translation-based feedback loops that control rhythmic transcription of a substantial fraction of these transcriptomes, yielding the changes in protein...
Resource Type:: Article

Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response

Creator:: Vidal-Dupiol, Jeremie, Dheilly, Nolwenn M., Rondon, Rodolfo, Smith, Kristina M., Freitag, Michael, Grunau, Christoph, Cosseau, Celine, Adjeroud, Mehdi, and Mitta, Guillame
Abstract:: Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and pathogens, and has affected host immunity, pathogen virulence and growth rates. This has resulted in increased disease in natural plant and animal populations worldwide, including scleractinian corals. While the effects of temperature increase...
Resource Type:: Article

Genome-Wide Characterization of Light-Regulated Genes in Neurospora crassa

Creator:: Wu, Cheng, Yang, Fei, Smith, Kristina M., Peterson, Matthew, Dekhang, Rigzin, Zhang, Ying, Zucker, Jeremy, Bredeweg, Erin L., Mallappa, Chandrashekara, Zhou, Xiaoying, Lyubetskaya, Anna, Townsend, Jeffrey P., Galagan, James E., Freitag, Michael, Dunlap, Jay C., Bell-Pedersen, Deborah, and Sachs, Matthew S.
Abstract:: The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for 0 (control) 15,...
Resource Type:: Article

Heterochromatin Controls γH2A Localization in Neurospora crassa

Creator:: Sasaki, Takahiko, Lynch, Kelsey L., Mueller, Caitlin V., Friedman, Steven, Freitag, Michael, and Lewis, Zachary A.
Abstract:: In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Resource Type:: Article

ScholarsArchive@OSU

The kinetochore interaction network (KIN) of ascomycetes

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

Genome‐wide identification of target genes of a mating‐type α‐domain transcription factor reveals functions beyond sexual development

Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function

Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential

Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response

Genome-Wide Characterization of Light-Regulated Genes in Neurospora crassa

Heterochromatin Controls γH2A Localization in Neurospora crassa

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