Index Catalog // ScholarsArchive@OSU

Creator:: Hurley, Jennifer M., Dasgupta, Arko, Emerson, Jillian M., Smith, Kristina M., Freitag, Michael, Zhou, Xiaoying, Ringelberg, Carol S., Knabe, Nicole, Lipzen, Anna, Linduist, Erika A., Daum, Christopher G., Barry, Kerrie W., Grigoriev, Igor V., Galagan, James E., Bell-Pederson, Deborah, Cheng, Chao, Loros, Jennifer J., and Dunlap, Jay C.
Abstract:: Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic fungal and animal clocks comprise transcription-translation-based feedback loops that control rhythmic transcription of a substantial fraction of these transcriptomes, yielding the changes in protein...
Resource Type:: Article

Creator:: Sasaki, Takahiko, Lynch, Kelsey L., Mueller, Caitlin V., Friedman, Steven, Freitag, Michael, and Lewis, Zachary A.
Abstract:: In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Resource Type:: Article

Creator:: Karimi-Aghcheh, Razieh, Bok, Jin Woo, Phatale, Pallavi A., Smith, Kristina M., Baker, Scott E., Lichius, Alexander, Omann, Markus, Zeilinger, Susanne, Seiboth, Bernhard, Rhee, Catherine, Keller, Nancy P., Freitag, Michael, and Kubicek, Christian P.
Abstract:: The putative methyltransferase LaeA is a global regulator that affects the expression of multiple secondary metabolite gene clusters in several fungi, and it can modify heterochromatin structure in Aspergillus nidulans. We have recently shown that the LaeA ortholog of Trichoderma reesei (LAE1), a fungus that is an industrial producer of...
Resource Type:: Article

Creator:: Puckett, Susan E., Reese, Kaleb A., Mitev, Georgi M., Mullen, Valerie, Johnson, Rudd C., Pomraning, Kyle R., Mellbye, Brett L., Tilley, Lucas D., Iversen, Patrick L., Freitag, Michael, and Geller, Bruce L.
Abstract:: Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit bacterial gene expression. (RFF)₃RXB- AcpP PPMO (R, arginine; F, phenylalanine; X, 6-aminohexanoic acid; B, β-alanine) is complementary to 11 bases of the essential gene acpP (encodes acyl carrier protein). The MIC of (RFF)₃RXB-AcpP was 2.5...
Resource Type:: Article

Creator:: Lepesant, Julie M. J., Cosseau, Celine, Boissier, Jerome, Freitag, Michael, Portela, Julien, Climent, Deborah, Perrin, Cecile, Zerlotini, Adhemar, and Grunau, Christoph
Abstract:: Background: In the leuphotrochozoan parasitic platyhelminth Schistosoma mansoni, male individuals are homogametic (ZZ) whereas females are heterogametic (ZW). To elucidate the mechanisms that led to the emergence of sex chromosomes, we compared the genomic sequence and the chromatin structure of male and female individuals. As for many eukaryotes, the lower...
Resource Type:: Article

Creator:: Vining, Kelly J., Pomraning, Kyle R., Wilhelm, Larry J., Priest, Henry D., Pellegrini, Matteo, Mockler, Todd C., Freitag, Michael, and Strauss, Steven H.
Abstract:: Background: DNA cytosine methylation is an epigenetic modification that has been implicated in many biological processes. However, large-scale epigenomic studies have been applied to very few plant species, and variability in methylation among specialized tissues and its relationship to gene expression is poorly understood. Results: We surveyed DNA methylation from...
Resource Type:: Article

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