Dendrimers are well-defined, polymeric nanomaterials currently being investigated for biomedical applications such as medical imaging, gene therapy, and tissue targeted therapy. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The majority of studies exploring dendrimer toxicity...
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Full Text:
• Stacey L. Harper
Received: 7 August 2014 / Accepted: 14 November 2014 / Published online: 4 December
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
Adding nanoparticles (NPs) to metalworking fluids (MWFs) has been shown to improve performance in metal cutting. Zinc oxide nanoparticles (ZnO NPs) and titanium dioxide nanoparticles (TiO₂ NPs), for example, have exhibited the ability to improve lubricant performance, decrease the heat created by machining operations, reduce friction and wear, and enhance...
Gold nanoparticles (AuNPs) are increasingly used in biomedical applications,
hence understanding the processes that affect their biocompatibility and stability are of
significant interest. In this study, we assessed the stability of peptide-capped AuNPs and
used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact
of synthesis...
Full Text:
, Marilyn Mackiewicz 2 and Stacey L. Harper 1,*
1 Department of Environmental and Molecular Toxicology
Gold nanoparticles (AuNPs) are increasingly used in biomedical applications,
hence understanding the processes that affect their biocompatibility and stability are of
significant interest. In this study, we assessed the stability of peptide-capped AuNPs and
used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact
of synthesis...
Gold nanoparticles (AuNPs) are increasingly used in biomedical applications, hence understanding the processes that affect their biocompatibility and stability are of significant interest. In this study, we assessed the stability of peptide-capped AuNPs and used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact of synthesis...
As more engineered nanomaterials (eNM) are developed for a wide range of applications, it is crucial to minimize any unintended environmental impacts resulting from the application of eNM. To realize this vision, industry and policymakers must base risk management decisions on sound scientific information about the environmental fate of eNM,...
Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here,...