Index Catalog // ScholarsArchive@OSU

Sodium/Proton Antiporter Activity is Essential for Virulence of Yersinia pestis

Creator:: Faulkner, Wyatt J., Ghosh, Amit, Minato, Yusuke, Winogrodzki, Judith, Lind, Erin, Plano, Gregory V., Hinnebusch, Joseph B., Dibrov, Pavel, and Häse, Claudia C.
Abstract:: We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....
Resource Type:: Poster

Development of monoclonal antibody-based assays for the detection of Vibrio tubiashii zinc-metalloprotease (VtpA)

Creator:: Gharaibeh, Dima N., Biel, Frances M., and Häse, Claudia C.
Abstract:: Vibrio tubiashii has been linked to disease outbreaks in molluscan species, including oysters, geoducks, and clams. In particular, oyster hatcheries in the Pacific Northwest have been plagued by intermittent vibriosis since 2006. Accurate detection of vibrios, including V. tubiashii, is critical to the hatcheries in order to allow for rapid...
Resource Type:: Article
Full Text:: ) Dima N. Gharaibeh, Frances M. Biel, Claudia C. Häse PII: S0167-7012(13)00160-7 DOI: doi: 10.1016

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocating.pdf

Creator:: Minato, Yusuke, Fassio, Sara R., Reddekopp, Rylan L., and Häse, Claudia C.
Abstract:: Two virulence factors produced by Vibrio cholerae, cholera toxin (CT) and toxin-corregulated pilus (TCP), are indispensable for cholera infection. ToxT is the central regulatory protein involved in activation of CT and TCP expression. We previously reported that lack of a respiration-linked sodium-translocating NADH–ubiquinone oxidoreductase (Na⁺-NQR) significantly increases toxT transcription. In...
Full Text:: ., Fassio, S. R., Reddekopp, R. L., & Häse, C. C. (2014). Inhibition of the sodium-translocating NADH

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

Creator:: Minato, Yusuke, Fassio, Sara R., and Häse, Claudia C.
Abstract:: We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern...
Resource Type:: Article
Full Text:: Vibrio cholerae Yusuke Minato1, Sara R. Fassio2, Claudia C. Häse1,2* 1 Department of Biomedical

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure4.jpg

Creator:: Minato, Yusuke, Fassio, Sara R., Reddekopp, Rylan L., and Häse, Claudia C.
Abstract:: Two virulence factors produced by Vibrio cholerae, cholera toxin (CT) and toxin-corregulated pilus (TCP), are indispensable for cholera infection. ToxT is the central regulatory protein involved in activation of CT and TCP expression. We previously reported that lack of a respiration-linked sodium-translocating NADH–ubiquinone oxidoreductase (Na⁺-NQR) significantly increases toxT transcription. In...

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure3.jpg

Creator:: Minato, Yusuke, Fassio, Sara R., Reddekopp, Rylan L., and Häse, Claudia C.
Abstract:: Two virulence factors produced by Vibrio cholerae, cholera toxin (CT) and toxin-corregulated pilus (TCP), are indispensable for cholera infection. ToxT is the central regulatory protein involved in activation of CT and TCP expression. We previously reported that lack of a respiration-linked sodium-translocating NADH–ubiquinone oxidoreductase (Na⁺-NQR) significantly increases toxT transcription. In...

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure2.jpg

Creator:: Minato, Yusuke, Fassio, Sara R., Reddekopp, Rylan L., and Häse, Claudia C.
Abstract:: Two virulence factors produced by Vibrio cholerae, cholera toxin (CT) and toxin-corregulated pilus (TCP), are indispensable for cholera infection. ToxT is the central regulatory protein involved in activation of CT and TCP expression. We previously reported that lack of a respiration-linked sodium-translocating NADH–ubiquinone oxidoreductase (Na⁺-NQR) significantly increases toxT transcription. In...

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure1.jpg

Creator:: Minato, Yusuke, Fassio, Sara R., Reddekopp, Rylan L., and Häse, Claudia C.
Abstract:: Two virulence factors produced by Vibrio cholerae, cholera toxin (CT) and toxin-corregulated pilus (TCP), are indispensable for cholera infection. ToxT is the central regulatory protein involved in activation of CT and TCP expression. We previously reported that lack of a respiration-linked sodium-translocating NADH–ubiquinone oxidoreductase (Na⁺-NQR) significantly increases toxT transcription. In...

Inhibition of the sodium-translocating NADH-ubiquinone oxidoreductase [Na⁺-NQR] decreases cholera toxin production in Vibrio cholerae O1 at the late exponential growth phase

Creator:: Minato, Yusuke, Fassio, Sara R., Reddekopp, Rylan L., and Häse, Claudia C.
Abstract:: Two virulence factors produced by Vibrio cholerae, cholera toxin (CT) and toxin-corregulated pilus (TCP), are indispensable for cholera infection. ToxT is the central regulatory protein involved in activation of CT and TCP expression. We previously reported that lack of a respiration-linked sodium-translocating NADH–ubiquinone oxidoreductase (Na⁺-NQR) significantly increases toxT transcription. In...
Resource Type:: Article

ASM2012_NQR_Posterfinal-1.pptx

Creator:: Fassio, Sara R., Minato, Yusuke, Quinn, Matthew J., Faulkner, Wyatt J., and Hase, Claudia C.
Abstract:: We previously reported that inhibition of the Na⁺ translocating NADH:ubiquinone oxidoreductase (NQR), either by chemical inhibition or mutation, increased toxT transcription in Vibrio cholerae. In this study, we revealed that the nqr mutant strain showed similar phenotypes as the Escherichia coli NADH dehydrogenase I (nuo) mutant strain (e.g. growth defect...
Full Text:: . Nature 406:477-483. 2. Häse, C. C., and J. J. Mekalanos. 1999. Effects of changes in membrane sodium flux

ScholarsArchive@OSU

Sodium/Proton Antiporter Activity is Essential for Virulence of Yersinia pestis

Development of monoclonal antibody-based assays for the detection of Vibrio tubiashii zinc-metalloprotease (VtpA)

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocating.pdf

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure4.jpg

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure3.jpg

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure2.jpg

HaeseClaudiaVeterinaryMedicineInhibitionSodiumTranslocatingFigure1.jpg

Inhibition of the sodium-translocating NADH-ubiquinone oxidoreductase [Na⁺-NQR] decreases cholera toxin production in Vibrio cholerae O1 at the late exponential growth phase

ASM2012_NQR_Posterfinal-1.pptx

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