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  • Evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates

    Creator:
    Nelson, Kimberly J., Parsonage, Derek, Karplus, P. Andrew, and Poole, Leslie B.
    Abstract:
    Peroxiredoxins (Prxs) are very effective peroxide reducing enzymes, but also are susceptible to being oxidatively inactivated by their own substrates. The level of sensitivity to such hyperoxidation varies depending both on the enzyme involved and the type of peroxide substrate. For some Prxs, the hyperoxidation has physiological relevance, so it...
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    inducible (Jeong et al., 2012) and important for the survival of cells under low (10-20 M) peroxide

  • A Primer on Peroxiredoxin Biochemistry

    Creator:
    Karplus, P. Andrew
    Abstract:
    Peroxiredoxins (Prxs) were not recognized as a family of enzymes until the 1990s but are now known to be the dominant peroxidases in most organisms. Here, the history and fundamental properties of peroxiredoxins are briefly reviewed, with a special focus on describing how an exquisitely tunable balance between fully folded...
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    Article
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    . Cell Biol. 175:779-789; 2006. [57] Kil, I. S.; Lee, S. K.; Ryu, K. W.; Woo, H. A.; Hu, M. C.; Bae

  • Tuning of Peroxiredoxin Catalysis for Various Physiological Roles

    Creator:
    Perkins, Arden, Poole, Leslie B., and Karplus, P. Andrew
    Abstract:
    Peroxiredoxins (Prxs) make up an ancient family of enzymes that are the predominant peroxidases for nearly all organisms and play essential roles in reducing hydrogen peroxide, organic hydroperoxides, and peroxynitrite. Even between distantly related organisms, the core protein fold and key catalytic residues related to its cysteine-based catalytic mechanism have...
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    Article

  • Peroxiredoxins in Parasites

    Creator:
    Gretes, Michael C., Poole, Leslie B., and Karplus, P. Andrew
    Abstract:
    Significance: Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens. Recent Advances: Plasmodial and...
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    Article