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Filtering by: Subject Theophylline -- Physiological effect Creator Miaullis, John Bartley

In vivo and in vitro metabolism of 4-benzo(b)thienyl-N-methylcarbamate and 4-hydroxy benzothiophene by the white rat

Creator:

Miaullis, John Bartley

Abstract:

In vitro studies of Mobam (4-benzo(b)thienyl N-methylcarbamate) metabolism have demonstrated that at least three ether soluble metabolites are formed in a microsomal system fortified with reduced triphosphopyridine nucleotide (NADPH). One of the metabolites was identical to 4HBT (4-hydroxy benzothiophene), the phenol of Mobam. The other two metabolites did not possess...

Resource Type:

Masters Thesis

Full Text:

dependent on their stability in the physiological environment. In addition to ester cleavage, other
In vivo and in vitro metabolism of 4-benzo(b)thienyl-N-methylcarbamate and 4-hydroxy benzothiophene by the white rat

Creator:

Miaullis, John Bartley

Abstract:

In vitro studies of Mobam (4-benzo(b)thienyl N-methylcarbamate) metabolism have demonstrated that at least three ether soluble metabolites are formed in a microsomal system fortified with reduced triphosphopyridine nucleotide (NADPH). One of the metabolites was identical to 4HBT (4-hydroxy benzothiophene), the phenol of Mobam. The other two metabolites did not possess...

Resource Type:

Masters Thesis

Full Text:

dependent on their stability in the physiological environment. In addition to ester cleavage, other