Background—The effect of intensive blood pressure (BP) lowering on kidney function among individuals with established cerebrovascular disease and preserved estimated glomerular filtration rate (eGFR) is not established.
Methods and Results—Among 2610 participants randomized to a lower (<130 mm Hg) versus higher (130–149 mm Hg) systolic BP target with repeated measures...
The importance of high blood pressure (BP) and the effect of BP lowering in older adults remain controversial due to the mixed evidence in this population. Frailty status may resolve the apparently conflicting findings and identify subpopulations who share common risk. Emerging evidence demonstrates that low BP is associated with...
Background
As the U.S. population grows older, there is greater need to examine physical independence. Previous studies have assessed risk factors in relation to either disability or mortality, but an outcome that combines both is still needed.
Methods and Results
The Cardiovascular Health Study is a population‐based, prospective study where...
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States, many eligible adults remain untreated. We projected the cost-effectiveness of treating hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and monitoring costs, costs...
BACKGROUND: Whether limitation in ability to perform activities of daily living (ADL) or gait speed can identify subgroups of elders in whom the association of systolic (SBP) and diastolic (DBP) blood pressure with cardiovascular events and death differs is not well established.
METHODS: We evaluated whether ADL and gait speed...
BACKGROUND: Chronic kidney disease (CKD) and hyperuricemia often coexist and both conditions are increasing in prevalence in the U.S., although their shared role on cardiovascular risk remains highly debated.
STUDY DESIGN: Cross-sectional and longitudinal
SETTING AND PARTICIPANTS: Participants in the National Health and Nutrition Examination Survey (NHANES) from 1988 to...
OBJECTIVES: Subclinical vascular disease (SVD) contributes to the aging process and may decrease life expectancy. We aimed to determine the contribution of gradations of SVD to the likelihood of achieving longer survival, and to determine what allows some individuals to achieve longer survival in the presence of high SVD.
DESIGN:...
OBJECTIVE: The associations of some risk factors with cardiovascular disease (CVD) are attenuated in
older age; whereas others appear robust. The present study aimed to compare CVD risk factors across
older age. METHODS: Participants (n = 4883) in the Cardiovascular Health Study free of prevalent CVD,
were stratified into three...
Recent evidence has demonstrated the importance of kidney function in healthy aging. We examined the association between kidney function and change in cognitive function in 3,907 participants in the Cardiovascular Health Study, recruited from 4 U.S. communities, and studied from 1992 - 1999. Kidney function was measured by cystatin C-based...
BACKGROUND: Consumption of sugar-sweetened beverage (SSB) has risen over the past two decades, with over 10 million Californians drinking one or more SSB per day. High SSB intake is associated with risk of type 2 diabetes, obesity, hypertension, and coronary heart disease (CHD). Reduction of SSB intake and the potential...
Purpose: To determine if the associations among established risk factors and reduced kidney function vary by age.
Methods: We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal...
Objectives:
To examine the association between kidney function and all-cause mortality in octogenarians.
Design
Retrospective analysis of prospectively collected data.
Setting:
Community.
Participants:
Serum creatinine and cystatin C were measured in 1,053 Cardiovascular Health Study (CHS) All Stars participants.
Measurements:
Estimated glomerular filtration rate (eGFR) was determined using the Chronic...