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Creator:: Nelson, Kimberly J., Parsonage, Derek, Karplus, P. Andrew, and Poole, Leslie B.
Abstract:: Peroxiredoxins (Prxs) are very effective peroxide reducing enzymes, but also are susceptible to being oxidatively inactivated by their own substrates. The level of sensitivity to such hyperoxidation varies depending both on the enzyme involved and the type of peroxide substrate. For some Prxs, the hyperoxidation has physiological relevance, so it...
Resource Type:: Article
Full Text:: inducible (Jeong et al., 2012) and important for the survival of cells under low (10-20 M) peroxide

Creator:: Perkins, Arden, Poole, Leslie B., and Karplus, P. Andrew
Abstract:: Peroxiredoxins (Prxs) make up an ancient family of enzymes that are the predominant peroxidases for nearly all organisms and play essential roles in reducing hydrogen peroxide, organic hydroperoxides, and peroxynitrite. Even between distantly related organisms, the core protein fold and key catalytic residues related to its cysteine-based catalytic mechanism have...
Resource Type:: Article

Creator:: Gretes, Michael C., Poole, Leslie B., and Karplus, P. Andrew
Abstract:: Significance: Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens. Recent Advances: Plasmodial and...
Resource Type:: Article

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