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Creator:: Kent, Michael L., Buchner, Cari, Barton, Carrie, and Tanguay, Robert L.
Abstract:: Surface disinfection of fertilized fish eggs is widely used in aquaculture to reduce extraovum pathogens that may be released from brood fish during spawning, and this is routinely used in zebrafish (Danio rerio) research laboratories. Most laboratories use approximately 25-50 ppm unbuffered chlorine solution for 5-10 min. Treatment of embryos...
Resource Type:: Article
Full Text:: , Carrie Barton2 and Robert L. Tanguay2 3 1Department of Microbiology, Oregon State University, Corvallis

Creator:: Garcia, Abraham, Truong, Lisa, Johnson, Eric, Tanguay, Robert L., and Knecht, Andrea
Abstract:: The use of zebrafish in behavioral neuroscience is rapidly growing. Zebrafish can be assessed for alterations in multiple behavioral endpoints, creating opportunities to use this powerful model to identify chemicals that alter behavioral phenotypes. To evaluate the utility of zebrafish for neurotoxicity research, we designed custom instrumentation to evaluate numerous...
Full Text:: . Andrea Knecht Dr. Maret Traber Melissa McDougall Eric Johnson Carrie Barton Rest of Tanguay Lab Funding

Creator:: Garcia, Abraham, Truong, Lisa, Johnson, Eric, Tanguay, Robert L., and Knecht, Andrea
Abstract:: The use of zebrafish in behavioral neuroscience is rapidly growing. Zebrafish can be assessed for alterations in multiple behavioral endpoints, creating opportunities to use this powerful model to identify chemicals that alter behavioral phenotypes. To evaluate the utility of zebrafish for neurotoxicity research, we designed custom instrumentation to evaluate numerous...
Full Text:: Traber Melissa McDougall Eric Johnson Carrie Barton Rest of Tanguay Lab Funding USDA NIFA MSP Grant

Creator:: Chatterjee, Paroma, Padmanarayana, Murugesh, Abdullah, Nazish, Holman, Chelsea L., LaDu, Jane, Tanguay, Robert L., and Johnson, Colin P.
Abstract:: Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been studied almost exclusively in mouse models, and no rescue experiments have...
Full Text:: . L., & Johnson, C. P. (2015). Otoferlin Deficiency In Zebrafish Results In Defects In Balance And

Creator:: Mandrell, David, Moore, Aaron, Jephson, Caleb, Sarker, Mushfiqur R., Lang, Christopher, Truong, Lisa, Simonich, Michael T., and Tanguay, Robert L.
Abstract:: The potential of the developing zebrafish model for toxicology and drug discovery is limited by inefficient approaches to manipulating and chemically exposing zebrafish embryos—namely, manual placement of embryos into 96- or 384-well plates and exposure of embryos while still in the chorion, a barrier of poorly characterized permeability enclosing the...
Resource Type:: Research Paper
Full Text:: The authors wish to express their gratitude to Greg Gonnerman, Lindsey Chalker, Carrie Barton, Cari

Creator:: McDougall, Melissa Q., Choi, Jaewoo, Stevens, Jan F., Truong, Lisa, Tanguay, Robert L., and Traber, Maret G.
Abstract:: We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio) defined diets without...
Full Text:: observed beha- vioral defects and increased mortality. Acknowledgments The authors thank Carrie L. Barton

Creator:: Noyes, Pamela D., Haggard, Derik E., Gonnerman, Greg D., and Tanguay, Robert L.
Abstract:: Sharp increases in the use of flammable plastics and electronic devices coupled with stricter fire safety requirements have promoted the heavy use of flame retardant chemicals. While flame retardant use has increased, a great deal of uncertainty surrounds their safety with some evidence showing toxicity and risk to human and...
Full Text:: European and 48 Asian populations (Johnson-Restrepo and Kannan, 2009; Toms, et al., 2011). The

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