Index Catalog // ScholarsArchive@OSU

Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy

Creator:: Taratula, Olena, Schumann, Canan, Duong, Tony, Taylor, Karmin L., and Taratula, Oleh
Abstract:: Multifunctional theranostic platforms capable of concurrent near-infrared (NIR) fluorescence imaging and phototherapies are strongly desired for cancer diagnostic and treatment. However, integration of separate imaging and therapeutic components into nanocarriers results in complex theranostic systems with limited translational potential. A single agent-based theranostic nanoplatform, therefore, was developed for concurrent NIR...
Resource Type:: Article
Full Text:: Fluorescence Imaging and Combinatorial Anticancer Phototherapy Olena Taratula, Canan Schumann, Tony Duong

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

Creator:: Dani, Raj K., Schumann, Canan, Taratula, Olena, and Taratula, Oleh
Abstract:: Herein, we report the successful development of a novel nanosystem capable of an efficient delivery and temperature-triggered drug release specifically aimed at cancer. The water-soluble 130.1 ± 0.2 nm iron oxide nanoparticles (IONPs) were obtained via synthesis of a monodispersed iron oxide core stabilized with tetramethylammonium hydroxide pentahydrate (TMAOH), followed...
Resource Type:: Article
Full Text:: Release Dani, R. K., Schumann, C., Taratula, O., & Taratula, O. (2014). Temperature-tunable iron oxide

TaratulaOlehPharmacyNaphthalocyanine-Based_SupportingInformation.pdf

Creator:: Taratula, Olena, Doddapaneni, Bhuvana S., Schumann, Canan, Li, Xiaoning, Bracha, Shay, Milovancev, Milan, Alani, Adam W. G., and Taratula, Oleh
Abstract:: This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.chemmater.5b03128
Full Text:: Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy Olena Taratula, § Bhuvana

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

Creator:: Taratula, Olena, Dani, Raj Kumar, Schumann, Canan, Xu, Hong, Wang, Andrew, Song, Han, Dhagat, Pallavi, and Taratula, Oleh
Abstract:: A multifunctional tumor-targeting delivery system was developed and evaluated for an efficient treatment of drug-resistant ovarian cancer by combinatorial therapeutic modality based on chemotherapy and mild hyperthermia. The engineered iron oxide nanoparticle (IONPs)-based nanocarrier served as an efficient delivery vehicle for doxorubicin and provided the ability to heat cancer cells...
Resource Type:: Article
Full Text:: Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells Author: Olena Taratula Raj Kumar Dani Canan

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Creator:: Schumann, Canan, Taratula, Olena, Khalimonchuk, Oleh, Palmer, Amy L., Cronk, Lauren M., Jones, Carson V., Escalante, Cesar A., and Taratula, Oleh
Abstract:: This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based...
Resource Type:: Article
Full Text:: , PharmD a , Olena Taratula, PhD a , Oleh Khalimonchuk, PhD b , Amy L. Palmer, MS c , Lauren M. Cronk

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

Creator:: Taratula, Olena, Patel, Mehulkumar, Schumann, Canan, Naleway, Michael A., Pang, Addison J., He, Huixin, and Taratula, Oleh
Abstract:: We report a novel cancer-targeted nanomedicine platform for imaging and prospect for future treatment of unresected ovarian cancer tumors by intraoperative multimodal phototherapy. To develop the required theranostic system, novel low-oxygen graphene nanosheets were chemically modified with polypropylenimine dendrimers loaded with phthalocyanine (Pc) as a photosensitizer. Such a molecular design...
Resource Type:: Article
Full Text:: imaging-guided combinatorial phototherapy Taratula, O., Patel, M., Schumann, C., Naleway, M. A., Pang, A

TaratulaOlehPharmacyNaphthalocyanine-Based.pdf

Creator:: Taratula, Olena, Doddapaneni, Bhuvana S., Schumann, Canan, Li, Xiaoning, Bracha, Shay, Milovancev, Milan, Alani, Adam W. G., and Taratula, Oleh
Abstract:: This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.chemmater.5b03128
Full Text:: Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy Olena Taratula, § Bhuvana

Naphthalocyanine-Based Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy

Creator:: Taratula, Olena, Doddapaneni, Bhuvana S., Schumann, Canan, Li, Xiaoning, Bracha, Shay, Milovancev, Milan, Alani, Adam W. G., and Taratula, Oleh
Abstract:: Image-guided phototherapy is extensively considered as a promising therapy for cancer treatment. To enhance translational potential of this modality, we developed a single agent-based biocompatible nanoplatform that provides both real time near-infrared (NIR) fluorescence imaging and combinatorial phototherapy with dual photothermal and photodynamic therapeutic mechanisms. The developed theranostic nanoplatform consists...
Resource Type:: Article

Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues

Creator:: Park, Youngrong, Korzun, Tetiana, Moses, Abraham S., Singh, Prem, Levasseur, Peter R., Demessie, Ananiya A., Sharma, Kongbrailatpam Shitaljit, Morgan, Terry, Raitmayr, Constanze J., Avila, Uriel, Sabei, Fahad Y., Taratula, Olena R., Marks, Daniel L., and Taratula, Oleh
Abstract:: Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
Resource Type:: Article
Full Text:: . Raitmayr, Uriel Avila, Fahad Y. Sabei, Olena R. Taratula, Daniel L. Marks*, and Oleh Taratula* Y

Intraperitoneal Nanotherapy for Metastatic Ovarian Cancer Based on siRNA-Mediated Suppression of DJ-1 Protein Combined with a Low Dose of Cisplatin

Creator:: Schumann, Canan, Chan, Stephanie, Millar, Jess A., Bortnyak, Yuliya, Carey, Katherine, Fedchyk, Alex, Wong, Leon, Korzun, Tetiana, Moses, Abraham S., Lorenz, Anna, Shea, Delaney, Taratula, Olena, Khalimonchuk, Oleh, and Taratula, Oleh
Abstract:: Herein, we report an efficient combinatorial therapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin. DJ-1 protein modulates, either directly or indirectly, different oncogenic pathways that support and promote survival, growth, and invasion of ovarian cancer cells. To evaluate the...
Resource Type:: Article
Full Text:: Lorenz, MSa, Delany Sheaa, Olena Taratula, PhDa, Oleh Khalimonchuk, PhDc,d, and Oleh Taratula, PhDa

ScholarsArchive@OSU

Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

TaratulaOlehPharmacyNaphthalocyanine-Based_SupportingInformation.pdf

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

TaratulaOlehPharmacyNaphthalocyanine-Based.pdf

Naphthalocyanine-Based Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy

Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues

Intraperitoneal Nanotherapy for Metastatic Ovarian Cancer Based on siRNA-Mediated Suppression of DJ-1 Protein Combined with a Low Dose of Cisplatin

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