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Probing the orientation of electrostatically immobilized cytochrome C by time of flight secondary ion mass spectrometry and sum frequency generation spectroscopy

Creator:

Baio, Joe E., Weidner, Tobias, Ramey, Dennis, Pruzinsky, Leah, and Castner, David G.

Abstract:

By taking advantage of the electron pathway through the heme group in cytochrome c (CytoC) electrochemists have built sensors based upon CytoC immobilized onto metal electrodes. Previous studies have shown that the electron transfer rate through the protein is a function of the position of this heme group with respect...

Resource Type:

Article

Full Text:

2084927726102116 1..8 Baio et al. Biointerphases 2013, 8:18 http
Differential surface activation of the A1 domain of von Willebrand factor

Creator:

Tronic, Elaine H., Yakovenko, Olga, Weidner, Tobias, Baio, Joe E., Penkala, Rebecca, Castner, David G., and Thomas, Wendy E.

Abstract:

The clotting protein von Willebrand factor (VWF) binds to platelet receptor glycoprotein Ibα (GPIbα) when VWF is activated by chemicals, high shear stress, or immobilization onto surfaces. Activation of VWF by surface immobilization is an important problem in the failure of cardiovascular implants, but is poorly understood. Here, the authors...

Resource Type:

Article

Full Text:

; wendyt@uw.edu 029803-1 Biointerphases 11(2), June 2016 1934-8630/2016/11(2)/029803/9 VC Author(s) 2016