Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbilical artery (n...
BACKGROUND: The relationship between arsenic and birth weight is not well understood.
OBJECTIVE: To evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential mediation effects of gestational age (GA) and maternal weight gain (MWG) during pregnancy using structural equation models (SEMs).
METHODS: A prospectively enrolled...
Although surfers have high incidental exposure to marine waters, no studies have investigated if surfer risk behaviors (such as surfing during advisories, near an outfall, during a rain event, or use of personal protective equipment) increase or decrease the risk of acquiring waterborne illnesses. We used a web-based survey to...
Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n=37), umbilical artery (n=45) and human...
Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Background: Arsenic is an immunotoxicant. Clinical reports observe the reactivation of varicella zoster virus (VZV) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leukemia that have been treated with arsenic trioxide. Objective: We evaluated the association between arsenic and the seroprevalence of VZV IgG...
Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer
stem cells (CSCs) and tumor progression through both autocrine and paracrine signaling. Elevated
production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has
been shown to increase CSC proliferation and tumor growth....
Although it is known that polycyclic aromatic hydrocarbons (PAHs) can be found in smoked meats, little is known about their prevalence in Native American smoked fish. In this work, the effect of traditional Native American fish smoking methods on dietary exposure to PAHs and possible risks to human health has...