Index Catalog // ScholarsArchive@OSU

Immunohistochemical Characterization of Intestinal Neoplasia in Zebrafish (Danio rerio) Indicates Epithelial Origin

Creator:: Paquette, Colleen E., Kent, Michael L., Peterson, Tracy S., Wang, Rong, Dashwood, Roderick H., and Löhr, Christiane V.
Abstract:: Spontaneous neoplasia of the intestinal tract in sentinel and moribund zebrafish (Danio rerio) is common in some zebrafish facilities. We previously classified these tumors as adenocarcinoma, small-cell carcinoma, or carcinoma otherwise unspecified based on histomorphologic characteristics. Based on histological presentation, the primary differential diagnosis for the intestinal carcinomas was tumor...
Resource Type:: Article

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

Creator:: Rajendran, Praveen, Dashwood, Wan-Mohaiza, Li, Li, Kang, Yuki, Kim, Eunah, Johnson, Gavin, Fischer, Kay A., Löhr, Christiane V., Williams, David E., Ho, Emily, Yamamoto, Masayuki, Lieberman, David A., and Dashwood, Roderick H.
Abstract:: Background: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies. Results: Wild type...
Resource Type:: Article

An epigenetic perspective on pharmacologic ascorbate in colon cancer

Creator:: Kaiser, Matthew Carl, Rajendran, Praveen, Dashwood, Mohaiza W., Levine, Mark A., Michels, Alexander, Frei, Balz, and Dashwood, Roderick H.
Abstract:: Aim: There is growing interest in pharmacologic ascorbate (Asc) and its therapeutic properties (Levine et al. Adv Nutr 2011;2:78). W e examined cell viability, histone deacetylase (HDAC) expression, and related protein modifications in cancer versus non- cancer colon epithelial cells following exposure to Asc. Methods: MTT assays were conducted in...
Resource Type:: Video, Presentation, and Other

Heterogeneous Reactions of PM-Bound PAHs and NPAHs with NO₃/N₂O₅, OH Radicals, and O₃ under Simulated Long-Range Atmospheric Transport Conditions: Reactivity and Mutagenicity

Creator:: Jariyasopit, Narumol, Zimmermann, Kathryn, Schrlau, Jill, Arey, Janet, Atkinson, Roger, Yu, Tian-Wei, Dashwood, Roderick H., Tao, Shu, and Simonich, Staci L. Massey
Abstract:: The heterogeneous reactions of ambient particulate matter (PM)-bound polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs (NPAHs) with NO₃/N₂O₅, OH radicals, and O₃ were studied in a laboratory photochemical chamber. Ambient PM[subscript 2.5] and PM₁₀ samples were collected from Beijing, China and Riverside, California, and exposed under simulated atmospheric long-range transport conditions...
Resource Type:: Article

Novel Nitro-PAH Formation from Heterogeneous Reactions of PAHs with NO₂, NO₃/N₂O₅, and OH Radicals: Prediction, Laboratory Studies and Mutagenicity

Creator:: Jariyasopit, Narumol, McIntosh, Melissa, Zimmermann, Kathryn, Arey, Janet, Atkinson, Roger, Cheong, Paul Ha-Yeon, Carter, Rich G., Yu, Tian-Wei, Dashwood, Roderick H., and Simonich, Staci L. Massey
Abstract:: The heterogeneous reactions of benzo[a]pyrene-d₁₂ (BaP-d₁₂), benzo[k]fluoranthene-d₁₂ (BkF-d₁₂), benzo[ghi]perylene-d₁₂ (BghiP-d₁₂), dibenzo[a,i]pyrene-d₁₄ (DaiP-d₁₄), and dibenzo[a,l]pyrene (DalP) with NO₂, NO₃/N₂O₅, and OH radicals were investigated at room temperature and atmospheric pressure in an indoor Teflon chamber and novel mono NO₂-DaiP, and mono NO₂-DalP products were identified. Quartz fiber filters (QFF) were used...
Resource Type:: Article

Plasma metabolites altered by sulforaphane in humans

Creator:: Kelsey, Kimberly J., Atwell, Lauren L., Clarke, John D., Hsu, Anna, Bella, Deborah, Stevens, Jan F., Dashwood, Roderick H., Williams, David E., and Ho, Emily
Abstract:: Consuming cruciferous vegetables such as broccoli sprouts, kale, Brussels sprouts, and bok choy is associated with several health benefits, such as a decreased risk of certain cancers. Cruciferous vegetables contain the glucosinolate, glucoraphanin (GFN). Cutting, chopping or chewing these vegetables releases the enzyme myrosinase, which transforms GFN into sulforaphane (SFN)....
Resource Type:: Poster

Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3′-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...
Resource Type:: Article

Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention

Creator:: Watson, Gregory, Beaver, Laura M., Williams, David, Dashwood, Roderick H., and Ho, Emily
Abstract:: Epidemiological evidence has demonstrated a reduced risk of prostate cancer associated with cruciferous vegetable intake. Follow-up studies have attributed this protective activity to the metabolic products of glucosinolates, a class of secondary metabolites produced by crucifers. The metabolic products of glucoraphanin and glucobrassicin, sulforaphane and indole-3-carbinol respectively, have been the...
Resource Type:: Article

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

Creator:: Lee, Seong-Ho, Richardson, Raphael L., Dashwood, Roderick H., and Baek, Seung Joan
Abstract:: Capsaicin is a pungent ingredient in chili red peppers and has been linked to suppression of growth in various cancer cells. However, the underlying mechanism(s) by which capsaicin induces growth arrest and apoptosis of cancer cells is not completely understood. In the present study, we investigated whether capsaicin alters β-catenin-dependent...
Resource Type:: Article

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:: Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.
Abstract:: Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Resource Type:: Article

ScholarsArchive@OSU

Immunohistochemical Characterization of Intestinal Neoplasia in Zebrafish (Danio rerio) Indicates Epithelial Origin

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

An epigenetic perspective on pharmacologic ascorbate in colon cancer

Heterogeneous Reactions of PM-Bound PAHs and NPAHs with NO₃/N₂O₅, OH Radicals, and O₃ under Simulated Long-Range Atmospheric Transport Conditions: Reactivity and Mutagenicity

Novel Nitro-PAH Formation from Heterogeneous Reactions of PAHs with NO₂, NO₃/N₂O₅, and OH Radicals: Prediction, Laboratory Studies and Mutagenicity

Plasma metabolites altered by sulforaphane in humans

Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

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