Transcription factors with multiple post-translational modifications (PTMs) are not uncommon, but comprehensive information on site-specific dynamics and interdependence is comparatively rare. Assessing dynamic changes in the extent of PTMs has the potential to link multiple sites both to each other and to biological effects observable on the same time scale....
Transcription factors comprise just over 7% of the human
proteome and serve as gatekeepers of cellular function,
integrating external signal information into gene expression programs that reconfigure cellular physiology at the
most basic levels. Surface-initiated cell signaling pathways converge on transcription factors, decorating these
proteins with an array of post-translational...
Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...