MOTIVATION: Recently there has been increasing interest in the effects
of cell mixture on the measurement of DNA methylation, specifically
the extent to which small perturbations in cell mixture proportions can
register as changes in DNA methylation. A recently published set of
statistical methods exploits this association to infer changes...
MOTIVATION: Recently there has been increasing interest in the effects
of cell mixture on the measurement of DNA methylation, specifically
the extent to which small perturbations in cell mixture proportions can
register as changes in DNA methylation. A recently published set of
statistical methods exploits this association to infer changes...
MOTIVATION: Recently there has been increasing interest in the effects
of cell mixture on the measurement of DNA methylation, specifically
the extent to which small perturbations in cell mixture proportions can
register as changes in DNA methylation. A recently published set of
statistical methods exploits this association to infer changes...
Background: There has been a long-standing need in biomedical research for a method that quantifies the normally mixed composition of leukocytes beyond what is possible by simple histological or flow cytometric assessments. The latter is restricted by the labile nature of protein epitopes, requirements for cell processing, and timely cell...