N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...