Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Iversen, Patrick L. License Attribution 4.0 (CC BY 4.0)

Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease

Creator:

Punj, Sumit, Kopparapu, Prasad, Jang, Hyo Sang, Phillips, Jessica L., Pennington, Jamie, Rohlman, Diana, O'Donnell, Edmond, Iversen, Patrick L., Kolluri, Siva Kumar, and Kerkvliet, Nancy I.

Abstract:

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatment of immune-mediated diseases. To this end, we...

Resource Type:

Article