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Filtering by: Creator Kean, Kelsey M. Date issued sim 2014-07-08

Structure of a Sedoheptulose 7-Phosphate Cyclase: ValA from Streptomyces hygroscopicus

Creator:

Kean, Kelsey M., Codding, Sara J., Asamizu, Shumpei, Mahmud, Taifo, and Karplus, P. Andrew

Abstract:

Sedoheptulose 7-phosphate cyclases (SH7PCs) encompass three enzymes involved in producing the core cyclitol structures of pseudoglycosides and similar bioactive natural products. One such enzyme is ValA from Streptomyces hygroscopicus subsp. jinggangensis 5008 which makes 2-epi-5-epi-valiolone as part of the biosynthesis of the agricultural antifungal agent validamycin A. We present, as...

Resource Type:

Article