Index Catalog // ScholarsArchive@OSU

Creator:: Sheng, Yan, Lam, Phillip W., Shahab, Salmah, Santosa, Dwi Andreas, Proteau, Philip J., Zabriskie, T. Mark, and Mahmud, Taifo
Abstract:: Four new elaiophylin macrolides (1–4), together with five known elaiophylins (5–9), have been isolated from cultures of the Indonesian soil bacterium Streptomyces sp. ICBB 9297. The new compounds have macrocyclic skeletons distinct from those of the known dimeric elaiophylins in that one or both of the polyketide chains contain(s) an...
Resource Type:: Article

Creator:: Osborn, Andrew R., Almabruk, Khaled H., Holzwarth, Garrett, Asamizu, Shumpei, LaDu, Jane, Kean, Kelsey M., Karplus, P. Andrew, Tanguay, Robert L., Bakalinsky, Alan T., and Mahmud, Taifo
Abstract:: Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought...
Resource Type:: Article

Creator:: Guha, Gunjan, Lu, Wanli, Li, Shan, Liang, Xiaobo, Kulesz-Martin, Molly F., Mahmud, Taifo, Indra, Arup Kumar, and Ganguli-Indra, Gitali
Abstract:: Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7- deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma...
Resource Type:: Article

Creator:: Nigam, Aeshna, Almabruk, Khaled H., Saxena, Anjali, Yang, Jongtae, Mukherjee, Udita, Kaur, Hardeep, Kohli, Puneet, Kumari, Rashmi, Singh, Priya, Zakharov, Lev N., Singh, Yogendra, Mahmud, Taifo, and Lal, Rup
Abstract:: Rifamycin B, a product of Amycolatopsis mediterranei S699, is the precursor of clinically used antibiotics that are effective against tuberculosis, leprosy and AIDS related mycobacterial infections. However, prolonged usage of these antibiotics has resulted in the emergence of rifamycin resistant strains of Mycobacterium tuberculosis. As part of our effort to...
Resource Type:: Article

Creator:: Kean, Kelsey M., Codding, Sara J., Asamizu, Shumpei, Mahmud, Taifo, and Karplus, P. Andrew
Abstract:: Sedoheptulose 7-phosphate cyclases (SH7PCs) encompass three enzymes involved in producing the core cyclitol structures of pseudoglycosides and similar bioactive natural products. One such enzyme is ValA from Streptomyces hygroscopicus subsp. jinggangensis 5008 which makes 2-epi-5-epi-valiolone as part of the biosynthesis of the agricultural antifungal agent validamycin A. We present, as...
Resource Type:: Article

Creator:: Creason, Allison L., Vandeputte, Olivier M., Savory, Elizabeth A., Davis, Edward W., II, Putnam, Melodie L., Hu, Erdong, Swader-Hines, David, Mol, Adeline, Baucher, Marie, Prinsen, Els, Zdanowska, Magdalena, Givan, Scott A., El Jaziri, Mondher, Loper, Joyce E., Mahmud, Taifo, and Chang, Jeff H.
Abstract:: Members of Gram-positive Actinobacteria cause economically important diseases to plants. Within the Rhodococcus genus, some members can cause growth deformities and persist as pathogens on a wide range of host plants. The current model predicts that phytopathogenic isolates require a cluster of three loci present on a linear plasmid, with...
Resource Type:: Article

Creator:: Xie, Pengfei, Sheng, Yan, Ito, Takuya, and Mahmud, Taifo
Abstract:: Asukamycin, a member of the manumycin family of antibiotics, exhibits strong antibacterial, antifungal, and anti-neoplastic activities. However, its production in the wild-type strain of Streptomyces nodosus subsp. asukaensis ATCC 29757 is relatively low. Recently, the biosynthetic gene cluster for asukamycin was identified in the producing organism and among the 36...
Resource Type:: Article

Creator:: Cavalier, Michael C., Yim, Young-Sun, Asamizu, Shumpei, Neau, David, Almabruk, Khaled H., Mahmud, Taifo, and Lee, Yong-Hwan
Abstract:: The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Resource Type:: Article

ScholarsArchive@OSU