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  • MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancerFigures1-5.pdf

    Creator:
    Mathews, Christopher K.
    Abstract:
    Cancer was recognized as a genetic disease at least four decades ago, with the realization that the spontaneous mutation rate must increase early in tumorigenesis, to account for the many mutations in tumor cells as compared with their progenitor normal cells. The genetic basis for cancer was established also from...
    Full Text:
    reductase and dCMP deaminase shown to be mutagenic141 1992 Nucleotide pool “sanitation” shown to

  • MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancer.pdf

    Creator:
    Mathews, Christopher K.
    Abstract:
    Cancer was recognized as a genetic disease at least four decades ago, with the realization that the spontaneous mutation rate must increase early in tumorigenesis, to account for the many mutations in tumor cells as compared with their progenitor normal cells. The genetic basis for cancer was established also from...
    Full Text:
    authors to suggest that the base excision repair pathway is more efficient than nucleotide pool

  • Deoxyribonucleotide Metabolism, Mutagenesis, and Cancer

    Creator:
    Mathews, Christopher K.
    Abstract:
    Cancer was recognized as a genetic disease at least four decades ago, with the realization that the spontaneous mutation rate must increase early in tumorigenesis, to account for the many mutations in tumor cells as compared with their progenitor normal cells. The genetic basis for cancer was established also from...
    Resource Type:
    Article