Particles generated from wear of prosthesis joint bearing surfaces induce inflammation and promote pathological periprosthetic osteoclast-mediated bone resorption (osteolysis). Obesity increases the risk of prosthesis failure. However, despite being morbidly obese, leptin-deficient ob/ob mice are resistant to osteolysis. These findings suggest that leptin exerts effects that act to increase particle-induced...
A major barrier to air travel for people with disabilities is the general lack of accessible lavatories on board commercial passenger aircraft. A primary reason for this lack of greater accessibility is related to space. To design an airplane lavatory that is accessible, minimizes the risk of injury to both...