Index Catalog // ScholarsArchive@OSU

Creator:: Cardenas, Andres, Houseman, E. Andres, Baccarelli, Andrea A., Quamruzzaman, Quazi, Rahman, Mahmuder, Mostofa, Golam, Wright, Robert O., Christiani, David C., and Kile, Molly L.
Abstract:: Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbilical artery (n...
Resource Type:: Article

Creator:: Rodrigues, Ema G., Bellinger, David C., Valeri, Linda, Hasan, Md Omar Sharif Ibne, Quamruzzaman, Quazi, Golam, Mostofa, Kile, Molly L., Christiani, David C., Wright, Robert O., and Mazumdar, Maitreyi
Abstract:: Background: The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmental outcomes among Bangladeshi children. Methods: We evaluated...
Resource Type:: Article

Creator:: Kile, Molly L., Faraj, Joycelyn M., Ronnenberg, Alayne G., Quamruzzaman, Quazi, Rahman, Mahmudar, Mostofa, Golam, Afroz, Sakila, and Christiani, David C.
Abstract:: Background: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the...
Resource Type:: Article

Creator:: Kile, Molly L., Cardenas, Andres, Rodrigues, Ema, Mazumdar, Maitreyi, Dobson, Christine, Golam, Mostofa, Quamruzzaman, Quazi, Rahman, Mahmudar, and Christiani, David C.
Abstract:: BACKGROUND: The relationship between arsenic and birth weight is not well understood. OBJECTIVE: To evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential mediation effects of gestational age (GA) and maternal weight gain (MWG) during pregnancy using structural equation models (SEMs). METHODS: A prospectively enrolled...
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Creator:: Kile, Molly L., Rodrigues, Ema G., Mazumdar, Maitreyi, Dobson, Christine B., Diao, Nancy, Golam, Mostofa, Quamruzzaman, Quazi, Rahman, Mahmudar, and Christiani, David C.
Abstract:: BACKGROUND: Arsenic, a common groundwater pollutant, is associated with adverse reproductive health but few studies have examined its effect on maternal health. METHODS: A prospective cohort was recruited in Bangladesh from 2008–2011 (N = 1,458). At enrollment (<16 weeks gestational age [WGA]), arsenic was measured in personal drinking water using...
Resource Type:: Article

Creator:: Pan, Wen-Chi, Kile, Molly L., Seow, Wei Jie, Lin, Xihong, Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Lu, Quan, and Christiani, David C.
Abstract:: Abstract: Background: Chronic exposure to arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM) but the underlying molecular mechanism remains unclear. Objectives: This study evaluated the interaction between single nucleotide polymorphisms (SNPs) in genes associated with diabetes and arsenic exposure in drinking water on...
Resource Type:: Article

Creator:: Seow, Wei Jie, Pan, Wen-Chi, Kile, Molly L., Baccarelli, Andrea A., Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Lin, Xihong, and Christiani, David C.
Abstract:: BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. METHODS: A follow-up study of 550 individuals was conducted in 2009-2011 on...
Resource Type:: Article

Creator:: Kile, Molly L., Baccarelli, Andrea, Hoffman, Elaine, Tarantini, Letizia, Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Hsueh, Yu-Mei, Wright, Robert O., and Christiani, David C.
Abstract:: BACKGROUND: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. OBJECTIVES: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes. METHODS: Drinking-water and urine samples were collected when women were at <= 28 weeks gestation; the samples were analyzed for arsenic...
Resource Type:: Article

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