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Filtering by: Creator Rajendran, Praveen Language English [eng]

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

Creator:

Rajendran, Praveen, Dashwood, Wan-Mohaiza, Li, Li, Kang, Yuki, Kim, Eunah, Johnson, Gavin, Fischer, Kay A., Löhr, Christiane V., Williams, David E., Ho, Emily, Yamamoto, Masayuki, Lieberman, David A., and Dashwood, Roderick H.

Abstract:

Background: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies. Results: Wild type...

Resource Type:

Article
An epigenetic perspective on pharmacologic ascorbate in colon cancer

Creator:

Kaiser, Matthew Carl, Rajendran, Praveen, Dashwood, Mohaiza W., Levine, Mark A., Michels, Alexander, Frei, Balz, and Dashwood, Roderick H.

Abstract:

Aim: There is growing interest in pharmacologic ascorbate (Asc) and its therapeutic properties (Levine et al. Adv Nutr 2011;2:78). W e examined cell viability, histone deacetylase (HDAC) expression, and related protein modifications in cancer versus non- cancer colon epithelial cells following exposure to Asc. Methods: MTT assays were conducted in...

Resource Type:

Video, Presentation, and Other