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Filtering by: Creator Scheri, Richard C. Language English [eng]

Chlordecone Increased Subcellular Distribution of Scavenger Receptor Class B Type II to Murine Hepatic Microsomes without Altering Cytosolic Cholesterol Binding Proteins

Creator:

Scheri, Richard C., Lee, Junga, Barofsky, Douglas F., and Curtis, Lawrence R.

Abstract:

Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD), stimulated biliary excretion of exogenous CH up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or scavenger receptor class B type I (SR-BI)...

Resource Type:

Article
Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:

Scheri, Richard C.

Abstract:

Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...

Resource Type:

Dissertation