Pharmacokinetics of theophylline and N-7 substituted
theophylline in rabbits when administered alone and in
various combinations were investigated. This thesis has
four chapters dealing with etophylline and theophylline;
proxyphylline and theophylline; dyphylline and theophylline;
and etophylline, proxyphylline and dyphylline pharmacokinetics
when administered concomitantly. All chapters
are interrelated. Each chapter has...
Gastric retention time of single unit dosage forms in swine was found
to be much longer than in humans. It was concluded that swine are not a
good animal model to study GI transit time of nonerodable or slowly eroded
dosage forms. Noneradable and slowly eroded dosage forms used to...