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Creator:: McDougall, Melissa Q., Choi, Jaewoo, Stevens, Jan F., Truong, Lisa, Tanguay, Robert L., and Traber, Maret G.
Abstract:: We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio) defined diets without...
Resource Type:: Article

Creator:: Traber, Maret G., Leonard, Scott W., Bobe, Gerd, Fu, Xueyan, Saltzman, Edward, Grusak, Michael A., and Booth, Sarah L.
Abstract:: BACKGROUND: Little is known about α-tocopherol’s bioavailability as a constituent of food or its dependence on a subject’s age. OBJECTIVE: To evaluate the α-tocopherol bioavailability from food, we used collard greens grown in deuterated water (²H collard greens) as a source of deuterium-labeled (²H) α-tocopherol consumed by younger and older...
Resource Type:: Article

Creator:: Lebold, Katie M., Kirkwood, Jays S., Taylor, Alan W., Choi, Jaewoo, Barton, Carrie L., Miller, Galen W., La Du, Jane, Jump, Donald B., Stevens, Jan Frederik, Tanguay, Robert L., and Traber, Maret G.
Abstract:: To test the hypothesis that embryogenesis depends upon α-tocopherol (E) to protect embryo polyunsaturated fatty acids (PUFAs) from lipid peroxidation, new methodologies were applied to measure α-tocopherol and fatty acids in extracts from saponified zebrafish embryos. A solid phase extraction method was developed to separate the analyte classes, using a...
Resource Type:: Article

Creator:: Athinarayanan, Shaminie, Wei, Rongrong, Zhang, Min, Bai, Shaochun, Traber, Maret G., Yates, Katherine, Cummings, Oscar W., Molleston, Jean, Liu, Wanqing, and Chalasani, Naga
Abstract:: Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but with significant inter-individual variability in its efficacy. Cytochrome P450 4F2 (CYP4F2) is the major enzyme metabolizing Vit E, with two common genetic variants (V433M, rs2108622 and W12G, rs3093105) found to...
Resource Type:: Article

Creator:: Depner, Christopher M., Traber, Maret G., Bobe, Gerd, Kensicki, Elizabeth, Bohren, Kurt M., Milne, Ginger, and Jump, Donald B.
Abstract:: Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD) induced NASH in LDLR-/-...
Resource Type:: Article

Creator:: Miller, Galen W., Ulatowski, Lynn, Labut, Edwin M., Lebold, Katie M., Manor, Danny, Atkinson, Jeffrey, Barton, Carrie L., Tanguay, Robert L., and Traber, Maret G.
Abstract:: The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring...
Resource Type:: Article

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