Rifamycin B, a product of Amycolatopsis mediterranei S699, is the precursor of clinically used antibiotics that are effective against tuberculosis, leprosy and AIDS related mycobacterial infections. However, prolonged usage of these antibiotics has resulted in the emergence of rifamycin resistant strains of Mycobacterium tuberculosis. As part of our effort to...
Understanding fundamental uranyl polyoxometalate
(POM) chemistry in solution and the solid state is
the first step to defining its future role in the development
of new actinide materials and separation processes
that are vital to every step of the nuclear fuel cycle. Many
solid-state geometries of uranyl POMs have been...
The dipolar cylcoadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.