A major issue in non-inferiority trials is the controversial assumption of constancy,
namely that the active control has the same effect relative to placebo as in previous studies
comparing the active control with placebo. The constancy assumption is often in doubt, which
has motivated various methods that ‘discount’ the control...
A major issue in non-inferiority trials is the controversial assumption of constancy,
namely that the active control has the same effect relative to placebo as in previous studies
comparing the active control with placebo. The constancy assumption is often in doubt, which
has motivated various methods that ‘discount’ the control...
Chronic heavy alcohol consumption is a risk factor for cortical bone fractures in males. The increase in fracture
risk may be due, in part, to reduced bone quality. Intracortical (osteonal) bone remodeling is the principle
mechanism for maintaining cortical bone quality. However, it is not clear how alcohol abuse impacts...
A major issue in non-inferiority trials is the controversial assumption of constancy, namely that the active control has the same effect relative to placebo as in previous studies comparing the active control with placebo. The constancy assumption is often in doubt, which has motivated various methods that ‘discount’ the control...
While the experimental Alzheimer's drugs recently developed by pharmaceutical companies failed to stop the progression of Alzheimer's disease, clinicians strive to seek clues on how the patients would be when they visit back next year, based upon the patients' current clinical and neuropathologic diagnosis results. This is related to how...
OBJECTIVE: To estimate the interrater and intrarater reliability of endometriosis diagnosis and severity of disease among gynecologic surgeons viewing operative digital images.
METHODS: The study population comprised a random sample (n = 148 [36%]) of women who participated in the Endometriosis: Natural History, Diagnosis and Outcomes study. Four academic expert...
In diagnostic medicine, estimating the diagnostic accuracy of a group of raters or medical tests relative to the gold standard is often the primary goal. When a gold standard is absent, latent class models where the unknown gold standard test is treated as a latent variable are often used. However,...
Delta-sigma modulators are currently a very popular technique for making high-resolution
analog-to-digital and digital-to-analog converters. These oversampled data
converters have several advantages over conventional Nyquist-rate converters, including
an insensitivity to many analog component imperfections, a simpler antialiasing filter and
reduced accuracy requirements in the sample and hold. Though the initial...