This dissertation describes two different projects. The first is the development of an oral DNA vaccine delivery system for fish. A novel oral DNA vaccine delivery system was developed for Rainbow Trout by combining non-viral vectors (polycationic liposomes or polycationic polymer) to facilitate the DNA vaccine's uptake by cell membranes...
The pharmacokinetics of two antimicrobials were investigated in alpacas. Six healthy alpacas were each administered a single dose of 10 mg/kg of oxytetracycline by IV injection and IM injection. In addition, a single dose of 20 mg/kg of florfenicol by IV administration was given to alpacas in a separate study....
The pharmacokinetics and dose proportionality of ibuprofen were examined in African and Asian elephants after single dose administration of 4, 5 and 6 mg/kg and on multiple dose administration. Each elephant received all the three doses and plasma ibuprofen concentrations were measured by HPLC. Approximate linearity of ibuprofen pharmacokinetics in...
Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
A nifedipine sustained release dosage form was prepared by using hot-melt batch
coating. Substrates are sugar beads, mesh size 30-35. Stearic acid, Acid Triglyceride, and
carnauba wax were coating agents used to make single layer coated beads and multiple
layer coated beads containing nifedipine. Dissolution of nifedipine from the beads...
The first project of this thesis is an in vitro study. This study was performed with 8 hydrocortisone topical products on the market for the purpose of comparing one Tec Lab product, a Corticool gel, to the other seven common products on the market. The permeation of these products was...