Mismatch repair is one of the mechanisms by which cells ensure genomic
stability. Deficiencies in mismatch repair (MMR) increase mutation rates and cancer
risks. In the well-characterized methyl-directed Escherichia co/i system, MMR is
initiated by MutS, Mut L, and MutH proteins. The single MutS protein and the
single MutL protein...
In modern on-chip memories, an increasing demand for higher performance, lower power, reduced area, and improved robustness creates a rising need for advanced microarchitecture and circuit design techniques. Particularly in large-signal multi-ported register files, these advanced design techniques include: (i) multi-banked arrays, (ii) multi-frequency arrays, (iii) multi-bit width gating, (iv)...
Despite the importance of tropical forest ecosystems in the global carbon cycle, there have been few studies of carbon dynamics in this biome. The magnitude of carbon stocks in the tropics and their changes over time are poorly known since ground-based observations are lacking. In this study, total carbon stocks...
Whole ecosystem carbon dioxide (CO₂) exchange estimated with the eddy covariance (EC) technique has been central to studies on the responses of terrestrial ecosystems to disturbance and intra‐annual and interannual variations in climate, but challenges exist in understanding and reducing the uncertainty in estimates of net ecosystem exchange (NEE) of...
This dissertation has two objectives. The first objective is to determine where best to situate the study of mentoring (i.e. the 'making of scientists') on the landscape of the history of science and science studies. This task is accomplished by establishing mentoring studies as a link between the robust body...
Ireland's Catholic Church played an important role in the turn-of-the-century nationalism that shaped James Joyce's identity and writing; yet it also played an important part in preventing that nationalism from achieving its goals of autonomy and cultural independence. For Joyce, this was particularly evident in the dialects and
thought structures...
A number of bacterial species are capable of degrading the widespread environmental pollutant trichloroethylene (TCE) via aerobic cometabolism, but cytotoxic effects that can debilitate the microorganism often accompany this transformation. In this dissertation the effects of TCE degradation on the well-studied, toluene-oxidizing bacterium Burkholderia cepacia G4 were investigated at the...
The DNA mismatch repair (MMR) pathway maintains genomic stability and
reduces cancer risk (colorectal and other internal cancers) by correcting polymerase
errors and activating cell cycle checkpoints and apoptosis in response to DNA damage.
Few studies have examined the influence of commonly encountered environmental
mutagens/carcinogens on the etiology of MMR-deficient...