Index Catalog // ScholarsArchive@OSU

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Creator:: Thompson, Cynthia Sue
Abstract:: The effects of oligoribonucleotides of identical or similar sequences to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were investigated in Escherichia coli. The oligoribonucleotides were expected to bind to the target protein S8 and block its incorporation into the 30S subunit, resulting in a nonfunctional...
Resource Type:: Dissertation
Full Text:: long, depending on the species. In E. coli, S8 is 129 amino acids long with a molecular weight of

Mass spectrometric analysis of UV-crosslinked protein-nucleic acid complexes

Creator:: Doneanu, Catalin E.
Abstract:: The DNA-binding domains of E. coli uracil-DNA glycosylase (Ung) and human replication protein A (hRPA) were studied using a general protocol developed in our laboratory for probing protein-DNA interactions. The procedure involves purification and mass spectrometric analysis of the nucleopeptide-products of a tryptically digested UV-crosslinked protein-nucleic acid complex. In the...
Resource Type:: Dissertation
Full Text:: Analysis of UV- Crosslinked Protein-Nucleic Acid Complexes Abstract approved: F. Barofsky The DNA

Molecular mechanisms underlying the high oleic acid phenotype in sunflower

Creator:: Schuppert, Gunnar Felix
Abstract:: Wildtype sunflower typically produces 12-24% oleic acid (18:1) and 70-82% linoleic acid (18:2). High-oleic sunflower, by contrast, produces up to 80-94% oleic acid. The monounsaturated oleic acid has a greater oxidative stability than the polyunsaturated linoleic acid, predominant in wildtype sunflower, and has greater nutritional benefits than polyunsaturated and saturated...
Resource Type:: Dissertation
Full Text:: high oleic acid content. Overall, our understanding of the molecular mechanisms underlying the high

Factors contributing to the formation of CC-->TT tandem mutations

Creator:: Skinner, Amy M.
Abstract:: The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Resource Type:: Dissertation
Full Text:: Toxicology Head of the Department of Environmental and Molecular Toxicology

Characterization of UV-crosslinked protein-nucleic acid interfaces by Maldi MS and ESI MS/MS

Creator:: Gafken, Philip R.
Resource Type:: Dissertation
Full Text:: crosslinked to nucleic acids. Since these initial studies on peptide-nucleic acid complexes by FAB MS, major

Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

Creator:: Hicks, Joshua M.
Abstract:: This thesis involves analyses of 3₂-helices, a-helices and of the change in residual entropy of a protein upon chemical modification. Part of the long-term goal of understanding the formation, function and stability of proteins requires that all conformations be accurately assigned and structurally understood. By a statistical analysis of 258...
Resource Type:: Dissertation
Full Text:: : Analysis of Secondary Structures in Nucleic Acid Binding Proteins and Nuclear Magnetic Resonance

Cloning and characterization of GRASP, a novel retinoic acid-induced gene from P19 embryonal carcinoma cells

Creator:: Nevrivy, Daniel
Abstract:: Retinoic acid (RA) exerts important effects in the processes of vertebrate development, cellular growth and differentiation, and homeostasis. However, the mechanisms of action of RA in the control of cellular and developmental processes are incompletely understood, as the retinoid target genes have not been fully characterized. The goal of these...
Resource Type:: Dissertation
Full Text:: ." Nucleic Acids Res 20(21): 5729-5735. Kopan, R., G. Traska, et al. (1987). "Retinoids as important

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:: Shenvi, Swapna V.
Abstract:: Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
Resource Type:: Dissertation
Full Text:: OF THE DISSERTATION OF Swapna V. Shenvi for the degree of Doctor of Philosophy in Molecular

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Creator:: Smith, Anthony R.
Abstract:: The vascular endothelium is a single cell layer that lines the lumen of the entire vasculature. It is the site of synthesis of nitric oxide (NO), a vasodilatory compound synthesized by endothelial nitric oxide synthase (eNOS). NO causes intracellular calcium sequestration of the vascular smooth muscle cells, relaxing and dilating...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Molecular and Cellular Biology presented on February 11. 2005

Molecular and rheological characterization of hyaluronic acid : determination of its role in thrombin-catalyzed fibrin clotting and viscosupplementation of joints

Creator:: Barrett, Brandon J.
Abstract:: Three samples of the biopolymer hyaluronic acid (HA) were characterized in the following manner: the molecular weights were obtained via multi-angle laser light scattering; the intrinsic viscosities were calculated through dilute solution viscometry, and the rheology of HA solutions was determined with constant rate rotational viscometry and dynamical mechanical testing....
Resource Type:: Masters Thesis
Full Text:: hyaluronic acid (HA) were characterized in the following manner: the molecular weights were obtained via

ScholarsArchive@OSU

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Mass spectrometric analysis of UV-crosslinked protein-nucleic acid complexes

Molecular mechanisms underlying the high oleic acid phenotype in sunflower

Factors contributing to the formation of CC-->TT tandem mutations

Characterization of UV-crosslinked protein-nucleic acid interfaces by Maldi MS and ESI MS/MS

Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

Cloning and characterization of GRASP, a novel retinoic acid-induced gene from P19 embryonal carcinoma cells

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Molecular and rheological characterization of hyaluronic acid : determination of its role in thrombin-catalyzed fibrin clotting and viscosupplementation of joints

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