Fluorinated chemicals (FCs) have been used since the 1950s in many industrial and commercial applications because of their unique properties such as chemical inertness, resistance to heat and their ability to repel water and oils. Concerns regarding potential environmental or human health risk from FCs exposure have emerged due to...
Zebrafish, Danio rerio, are widely used as vertebrate research organisms yet little is know about their responses to husbandry stressors. This dissertation examined the whole-body cortisol responses of zebrafish to husbandry stress. Additionally, the effects of stress on the susceptibility to mycobacteriosis and microsporidiosis (Pseudoloma neurophilia) were determined including effects...
Dithiocarbamates are widely used agricultural pesticides, industrial chemicals and
effluent additives. DTCs and their related compounds have historical and current
relevance in clinical and experimental medicine. DTC developmental toxicity is well
established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a
mechanism of action involving, "the inhibition of...
The aim of this study was to assess sensitivity of early life stage zebrafish to cadmium (Cd). Embryos and larva were exposed to Cd before the formation of skeletal elements. Exposure times were selected to determine whether Cd perturbed developmental processes that lead to skeletal deformities, and to characterize the...
Effective treatment of larval bacterial diseases is a difficult problem when
culturing ornamental fish. Oral administration of antibiotics using existing
microparticle types is not effective due to high leakage rates; furthermore, injection of
larvae is not practical. Treatment is currently limited to use of antibiotic baths, . In this
study,...
Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...