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Filtering by: Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R. Decade 2010-2019 Remove constraint Decade: 2010-2019

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  • Part I: Total Syntheses of Mandelalide A and Isomandelalide A. Part II: Role of π-Stacking on Sharpless Dihydroxylation of cis-Enynes: Synthetic Studies Toward All Carbon Macrocyclic Mandelalide B

    Creator:
    Ghosh, Ankan
    Abstract:
    Part I of this dissertation includes the chronological synthetic background of mandelalide A as well as the synthesis of the C1-C14 glycosylated southern subunit of mandelalide. A key aspect of the synthesis includes a novel silver-catalyzed cyclization (AgCC) of a propargylic benzoate to construct the substituted cis-pyran ring system present...
    Resource Type:
    Dissertation
    Full Text:
    extend my thankfulness to Prof. Paul R. Blakemore and Prof. Sandra Loesgen with whom I took most of the

  • Exploring the Synthesis of 4-Deoxygadusol

    Creator:
    Jujjuri, Anantha Poojitha
    Abstract:
    Sunscreen products are used worldwide to protect the skin from ultraviolet radiation. However, some of the ingredients used in sunscreen products are fatal to coral reefs especially in areas where tourism is a large part of the economy. In this study, we explored a synthetic route to produce 4-deoxygadusol, which...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Paul Blakemore, Committee Member, representing Chemistry

  • Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

    Creator:
    Zhu, Chenxi
    Abstract:
    Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
    Resource Type:
    Dissertation
    Full Text:
    enantiomers. Red solid line: CAM-B3LYP/TZVP S (shift: 11 nm; σ = 0.66 eV), blue solid line: CAM-B3LYP/TZVP R

  • Bioprospecting the Chemical Diversity of Plant-associated Fungi

    Creator:
    González-Montiel, Gisela Abigail
    Abstract:
    Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
    Resource Type:
    Masters Thesis

  • Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

    Creator:
    Ju, Xuan
    Abstract:
    Dearomatization reactions exist broadly in biosynthesis and chemical synthesis. The highly functionalized atoms of arenes can be masked by it aromaticity, and upon dearomatization, those reactive atoms can be readily applied to bond formation and further manipulation. The total synthesis of (–)-cephalotaxine and (–)- homoharringtonine is described via an oxidative...
    Resource Type:
    Dissertation
    Full Text:
    .; Müller, M.; Hagedoorn, P.-L; Hagen, W. R.; Boll, M. J. Am. Chem. Soc. 2010, 132, 9850–9856. 2 a

  • Part I: Synthetic Studies Toward Mandelalide A and Madeirolide A; Part II: Synthesis of Mandelalide/Madeirolide Hybrid Structures

    Creator:
    Li, Jinming
    Abstract:
    Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures. Part I...
    Resource Type:
    Dissertation
    Full Text:
    all my graduate studies. I would also like to thank my graduate committee members, Professor Paul

  • Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

    Creator:
    Goswami, Subir
    Abstract:
    The furanyl diterpenoid family of natural products has drawn the attention of both synthetic organic chemists and pharmacologists due to their complex structural architectures and diverse biological activity. Among them, wortmannin has been most extensively studied for biological activities. All these furanyl diterpenoids consist of a highly strained naptha[1,8-bc]furan core,...
    Resource Type:
    Dissertation
    Full Text:
    References [1] Wipf, P.; Halter, R. J. Org. Biomol

  • Topological and Dynamical Properties of Cyclically Presented Groups

    Creator:
    McDermott, Kirk M.
    Abstract:
    This dissertation investigates the structure and topological properties of cyclicallypresented groups. First, a family of groups called groups of type Z is considered. Withfew exceptions, the finiteness, asphericity, fixed point, and 3-manifold spine problemsare solved. Most groups of type Z have a central element of infinite order fixed by theshift....
    Resource Type:
    Dissertation
    Full Text:
    ∂V/Zn, a Heegaard diagram for M/Zn ≈ L(r − s, |s|) . . . . . . . . . . . . . . . . . . . . 59 3.6

  • A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

    Creator:
    Saha, Mrinmoy
    Abstract:
    Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
    Resource Type:
    Dissertation
    Full Text:
    (both R and S) was also explored in the Michael reaction and (R)-C10-epimer proved to give better

  • Scanning photocurrent microscopy study of photovoltaic and thermoelectric effects in individual single-walled carbon nanotubes

    Creator:
    DeBorde, Tristan
    Abstract:
    Carbon Nanotubes are a unique family of nanostructures that have shown remarkable promise for mechanical, electrical, and optical applications. Fundamentally similar to the earlier discovered Buckminsterfullerene (C₆₀), carbon nanotubes are hollow cylinders formed from a single sheet of carbon atoms. The research presented in this dissertation investigates several carbon nanotube...
    Resource Type:
    Dissertation
    Full Text:
    . 12 1.5 References 1 Wilder, J. W. G., Venema, L. C., Rinzler, A. G., Smalley, R. E. & Dekker