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Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation
Full Text:: : John Mark Christensen The first part of the dissertation is to evaluate the use of proposed and

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: would like to thank my advisor, Dr. John Mark Christensen, who from the initial research stage was

Creator:: Karnpracha, Chanida
Abstract:: Pharmacokinetics (PK) is the study of the transit of drug into, within and removal from the body to reveal how the body acts on a drug when it is taken. There are four major areas in PK: absorption, distribution, metabolism and elimination. Pharmacokinetics research can be separated into two areas:...
Resource Type:: Masters Thesis
Full Text:: : J. Mark Christensen Pharmacokinetics (PK) is the study of the transit of drug into, within and

Creator:: Li, Wenjing
Abstract:: The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ John Mark Christensen The methodology to perform bioequivalence studies for prodrug

Creator:: Mustafa, Nizar Ahmad
Abstract:: Halogenated organic compounds have had widespread and massive applications in industry, agriculture, and private households, for example, as degreasing solvents, flame retardants and in polymer production. They are released to the environment through both anthropogenic and natural sources. The most common chlorinated solvents present as contaminants include tetrachloroethene (PCE, perchloroethene)...
Resource Type:: Dissertation
Full Text:: . committee members, Mark Dolan, Jack Istok, Brian Wood and John Baham for his role as Graduate Council

ScholarsArchive@OSU