Index Catalog // ScholarsArchive@OSU

Creator:: Doddapaneni, Bhuvana S.
Abstract:: Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
Resource Type:: Dissertation
Full Text:: Bhuvana S. Doddapaneni for the degree of Doctor of Philosophy in Pharmacy presented on June 9, 2016

Creator:: Mishra, Gyan P., Doddapaneni, Bhuvana Shyam, Nguyen, Duc, and Alani, Adam W. G.
Abstract:: PURPOSE: The in vitro inhibitory effect of Docetaxel (DTX) and Everolimus (EVR) alone and together in poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) nanocarriers on angiogenic processes and acute toxicity in mice was evaluated. METHODS: PEG-b-PLA DTX and/or EVR nanocarriers were characterized for size, drug loading, stability, and drug release. Cell proliferation, tubule...
Resource Type:: Article
Full Text:: Everolimus as individual and dual-drug loaded micellar nanocarriers Gyan P. Mishra, Bhuvana Shyam

Creator:: Hackman, Kayla M., Doddapaneni, Bhuvana Shyam, Barth, Connor W., Wierzbicki, Igor H., Alani, Adam W. G., and Gibbs, Summer L.
Abstract:: ACS Editors' Choice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Resource Type:: Article

Creator:: Taratula, Olena, Doddapaneni, Bhuvana S., Schumann, Canan, Li, Xiaoning, Bracha, Shay, Milovancev, Milan, Alani, Adam W. G., and Taratula, Oleh
Abstract:: Image-guided phototherapy is extensively considered as a promising therapy for cancer treatment. To enhance translational potential of this modality, we developed a single agent-based biocompatible nanoplatform that provides both real time near-infrared (NIR) fluorescence imaging and combinatorial phototherapy with dual photothermal and photodynamic therapeutic mechanisms. The developed theranostic nanoplatform consists...
Resource Type:: Article

Creator:: Kinser, Reid
Abstract:: Tacrolimus is an immunosuppressant drug approved by the FDA for the prevention of organ transplant rejection. However, the use of this drug is hindered by its narrow therapeutic window and extreme insolubility in water. Due to these properties, the currently used tacrolimus preparations must be administered once or twice daily...
Resource Type:: Honors College Thesis
Full Text:: , PhD Special Help Shyam Doddapaneni Adel Al Fatease Funding OSU College of Pharmacy

Creator:: Nguyen, Duc X.
Abstract:: TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
Resource Type:: Dissertation

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