Index Catalog // ScholarsArchive@OSU

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis
Full Text:: ” Rochefort, Phil Proteau and Adrian “Fritz” Gombart, and all the researchers who developed the use of

Characterization of novel exopolysaccharide producing lactic acid bacteria

Creator:: Garcia, Roberto A., III
Abstract:: Lactic Acid Bacteria (LAB), an important group of organisms in modern food production, are known to secrete a unique compound called exopolysaccharide (EPS). EPS is economically important because it enhances functional properties in food and may confer beneficial health effects to consumers. Novel strains of Lactococcus lactis, Streptococcus thermophilus, and...
Resource Type:: Masters Thesis
Full Text:: thanks to my committee members, Dr. Theo Dreher, Dr. Bruce Geller, and Dr. Adrian Gombart, for their

Impacts of microbial chemical interactions on marine plankton physiology

Creator:: Moore, Eric R.
Abstract:: The bioavailability of chemical compounds in the marine environment fundamentally influences the growth and physiology of microorganisms. Organic and inorganic chemicals that are produced by some marine plankton can be consumed by other plankton for energy production, growth, or to initiate essential physiological processes. Cultures of the diatom Thalassiosira pseudonana,...
Resource Type:: Dissertation

Cellulose Nanomaterial Incorporated Edible Coatings for Improving Storability of Postharvest Fruit: Mechanisms, Development and Validation

Creator:: Deng, Zilong
Abstract:: The overall objective of this dissertation study was to develop and validate the performance of cellulose nanomaterials (CNs) incorporated fruit coatings for improving the storability of postharvest pears and bananas under various storage conditions. Four specific studies were conducted to fulfill the research objectives as stated below. First, cellulose nanocrystal...
Resource Type:: Dissertation
Full Text:: Remcho and Dr. Adrian Gombart for serving as my graduate committee and providing me advices and

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Creator:: Sheng, Yan
Abstract:: The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
Resource Type:: Dissertation
Full Text:: Proteau, Dr. Jane Ishmael and Dr. Adrian Gombart for their generous time, support, advice and

Building a bridge from chromosomes to microtubules in Neurospora crassa

Creator:: Friedman, Steven
Abstract:: DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
Resource Type:: Dissertation

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:: Axton, Elizabeth R.
Abstract:: Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Resource Type:: Dissertation
Full Text:: Kioussi, and Adrian Fritz Gombart for their helpful feedback, support, and guidance. Thank you to all

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Creator:: Zamzow, Daniel R.
Abstract:: Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Resource Type:: Dissertation
Full Text:: good friend and colleague. I would like to thank my committee members: Fritz Gombart, Pat Chappell

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

Creator:: Bhattacharya, Shreya
Abstract:: The integumentary system is the largest organ system of the body that comprises of skin and its appendages such as hair follicles, sebaceous and sweat glands. Skin is divided into three distinct structural layers: the epidermis, dermis and hypodermis. The epidermis originates from the ectoderm and is composed of four...
Resource Type:: Dissertation

ScholarsArchive@OSU

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Characterization of novel exopolysaccharide producing lactic acid bacteria

Impacts of microbial chemical interactions on marine plankton physiology

Cellulose Nanomaterial Incorporated Edible Coatings for Improving Storability of Postharvest Fruit: Mechanisms, Development and Validation

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Building a bridge from chromosomes to microtubules in Neurospora crassa

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

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