Since 1939, scientists have studied estrous cycle manipulation in dogs resulting in more articles published in this field than any other area of canine reproduction. Estrous cycle manipulation in dogs must be safe and reliable. Dopamine agonists, gonadotropin-releasing hormone agonists, and gonadotropins are hormones that have been used for estrus...
Placental pathologies are not uncommon in dogs. For example, in primiparous bitches, the reported incidence of subinvolution of placental sites is 21% - 100%. Despite years of research in multiple species, the mechanisms regulating late gestation trophoblast behavior in the dog remain unexamined. Therefore, the objective of this study was...
Camelid health and parasitology experts disagree on what a “safe” level of internal parasitism is in camelids. The objective was to determine the levels of parasitism in show camelids (llamas and alpacas). The hypothesis was that fecal egg counts (FEC) in camelid would differ based upon geographic location, species (llama...
Sheep are seasonally polyestrus, which means they do exhibit estrus and ovulation during the short daylight (breeding season) and do not during the long daylight (nonbreeding season). To stimulate the ewes to ovulate during the nonbreeding season, various hormonal treatments have been used. PG-600 contains both equine chorionic gonadotropin and...
Gonadectomy has been associated with a 1.5-2 fold increase in the occurrence of canine hip dysplasia and a 2-3 fold increase in the occurrence of canine anterior cruciate ligament (ACL) injury. In intact dogs, luteinizing hormone (LH) is secreted from the adenohypophysis to stimulate the synthesis of gonadal hormones, which...
Reproductive function in the dog is controlled by feedback mechanisms that involve the hypothalamus, the anterior pituitary gland, and the gonads. Surgical gonad removal, a common procedure performed in dogs for the purposes of sterilization, disrupts the hypothalamic-pituitary-gonadal (HPG) axis and results in permanently elevated concentrations of gonadotropins. Manipulation of...
This research investigated gene expression in the canine placenta during the peripartum period. Previous studies have recognized molecular changes that occur in the placenta around the time of placental release in other species, but no study has looked at gene expression in the late gestation canine placenta. Of particular significance...
As bovine parturition nears, the placentome undergoes changes that allow placental delivery within 12 hours after calving. These changes include the expression of enzymatic proteins (e.g. MMPs) within the placentome that are capable of breaking down collagen, allowing for the separation of the cotyledon from the caruncle. Dysregulation of either...
Similar to the mammalian placenta with the chorioallantois and amnion, the avian yolk sac membrane (YSM) is comprised of the area vitellina (AVI) and area vasculosa (AVA), respectively. Understanding incorporation and delivery of nutrients (especially fatty acids) between these membranes and the developing embryo is important for improving hatchability and...
The purpose of this thesis was to determine if an underlying biological cause exists for the exuberant reproductive success in free-roaming unowned (FRU) cats. The hypothesis for this thesis was that FRU tom and queen cats have reproductively adapted to man-made sterilization efforts by lowering the age at which they...