Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
The illicit use of opioids among young adults (18–25) has resulted in an increase of clients needing substance abuse treatment. Treatment programs are struggling to keep up with the influx of these young adults. Traditional models of care have some impact; however, there are not enough treatment centers that can...
Through improved adherence, once-monthly injectable extended-release naltrexone (XR-NTX)
may provide an advantage over other oral agents approved for alcohol and opioid dependence
treatment. The objective of this study was to evaluate cost and utilization outcomes between
XR-NTX and other pharmacotherapies for treatment of alcohol and opioid dependence.
Published studies were...
Use of basalt aquifers for aquifer storage and recovery (ASR) systems is increasing in the Pacific Northwest due to the large aerial extent of the Columbia River Basalt Group and the suitability of basalts as ASR reservoirs. However, the degradation of trihalomethanes (THMs), potentially carcinogenic disinfection by-products present in the...
This thesis examines the recent history of the teaching of argument and its implications in the face of new writing standards being implemented in K-12 classrooms under the Common Core State Standards. The new educational policies will shift the focus of writing instruction onto argument writing as part of students'...
Currently, fungicide applications are the predominant method of control for the cool weather pathogen Microdochium patch (Microdochium nivale). Increasing pesticide restrictions have generated concern regarding management of Microdochium patch. Three separate field trials exploring non-traditional fungicides were conducted between 2013 and 2015 on an annual bluegrass (Poa annua L.) sand-based...
Children's early self-regulation skills have long-term implications for a variety of academic, social, and health outcomes. Unfortunately, children facing multiple family risk factors (e.g., harsh parenting, economic disadvantage) are more likely to struggle with early self-regulation. Despite early disparities in self-regulation, promising intervention evidence suggests that high quality prekindergarten experiences...
Seeds provide food, feed, fiber and fuel. They are also an important delivery system of genetic information, which is essential for the survival of wild species in ecosystems and the production of agricultural crops. In this review, seed traits and genes that are potentially important for agricultural applications are discussed....
Currently the production of biofuel from algae is not economically competitive with petroleum fuel. However, co-production of high-value products may be able to justify the cost of large-scale algae cultivation. The basic goal of this study is to develop a techno-economic analysis (TEA) and Life-cycle assessment (LCA) for the production...
Further enhancement of energy generation is desired for practical application of anaerobic microbial systems such as microbial fuel cells (MFC) and anaerobic digesters (AD). A possible approach is to enhance the ability of microbial communities to transfer electron extracellularly in the form of electrical current. Critical to perform direct extracellular...