Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Better Bones and Balance (BBB) is a community-based exercise program to improve bone health and reduce fall risk among older adults. Prior research has shown that when the program is delivered by researchers under controlled conditions, participants improved strength and balance, and maintained bone mineral density (BMD) at the hip....
Pathogenic mycobacteria are important agents causing human disease. Mycobacterium avium subsp. hominissuis
(M. avium) is a species of recalcitrant environmental pathogen. The bacterium forms robust biofilms that allow it to
colonize and persist in austere environments, such as residential and commercial water systems. M. avium is also an
opportunistic pathogen...
Background: Osteosarcoma (OSA) is the most common primary bone tumor of dogs and carries a poor prognosis
despite aggressive treatment. An improved understanding of the biology of OSA is critically needed to allow for
development of novel diagnostic, prognostic, and therapeutic tools. The surface-exposed proteome (SEP) of a
cancerous cell...
Transitional cell carcinoma (TCC), the most common cancer of the urinary bladder in dogs, is usually diagnosed at an advanced disease stage with limited response to chemotherapy. Commercial screening tests lack specificity and current diagnostic procedures are invasive. A proof of concept pilot project for analyzing the canine urinary proteome...
Osteoporotic vertebral fractures are a common and costly public health problem with a high occurrence in older women due to menopausal-onset bone loss. Recent findings suggest that mechanical loading created by upper body resistance training can stimulate bone growth in the lumbar spine, reducing osteoporosis-related bone loss and associated fracture...
Rapid adaptation and evolution based on standing genetic variation and novel mutations is likely to be one of the primary ways that species survive the widespread anthropogenic environmental changes expected of the next century. Three-spined stickleback (Gasterosteus aculeatus) are known to be capable of extremely quick, dramatic adaptation in response...
Due to a combination of misinterpretation and misleading illustration, the premise of a “tongue map”, which indicated that sweetness could only be detected at the front of the tongue and bitterness could only be detected on the back, became wide spread. In fact, all taste qualities can be detected on...
Respiratory infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium avium, can lead to progressive, recurrent disease that is refractory to therapy. Bacterial biofilms are intrinsically resistant to a variety of stressors and pressures, including host killing mechanisms and antibiotic therapy. Though it is becoming increasingly evident that NTM biofilms are...
Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae and is a deadly pathogen for koi and common carp, Cyprinus carpio. It causes severe gill necrosis and nephritis, dermal ulceration and hemorrhage, and mass mortality of up to 100% of affected fish. Fish...