Index Catalog // ScholarsArchive@OSU

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Canan Schumann for the degree of Doctor of Philosophy in

Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy

Creator:: Taratula, Olena, Schumann, Canan, Duong, Tony, Taylor, Karmin L., and Taratula, Oleh
Abstract:: Multifunctional theranostic platforms capable of concurrent near-infrared (NIR) fluorescence imaging and phototherapies are strongly desired for cancer diagnostic and treatment. However, integration of separate imaging and therapeutic components into nanocarriers results in complex theranostic systems with limited translational potential. A single agent-based theranostic nanoplatform, therefore, was developed for concurrent NIR...
Resource Type:: Article
Full Text:: Fluorescence Imaging and Combinatorial Anticancer Phototherapy Olena Taratula, Canan Schumann, Tony Duong

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

Creator:: Dani, Raj K., Schumann, Canan, Taratula, Olena, and Taratula, Oleh
Abstract:: Herein, we report the successful development of a novel nanosystem capable of an efficient delivery and temperature-triggered drug release specifically aimed at cancer. The water-soluble 130.1 ± 0.2 nm iron oxide nanoparticles (IONPs) were obtained via synthesis of a monodispersed iron oxide core stabilized with tetramethylammonium hydroxide pentahydrate (TMAOH), followed...
Resource Type:: Article
Full Text:: Release Dani, R. K., Schumann, C., Taratula, O., & Taratula, O. (2014). Temperature-tunable iron oxide

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Creator:: Schumann, Canan, Taratula, Olena, Khalimonchuk, Oleh, Palmer, Amy L., Cronk, Lauren M., Jones, Carson V., Escalante, Cesar A., and Taratula, Oleh
Abstract:: This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based...
Resource Type:: Article
Full Text:: Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression Canan Schumann

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

Creator:: Taratula, Olena, Dani, Raj Kumar, Schumann, Canan, Xu, Hong, Wang, Andrew, Song, Han, Dhagat, Pallavi, and Taratula, Oleh
Abstract:: A multifunctional tumor-targeting delivery system was developed and evaluated for an efficient treatment of drug-resistant ovarian cancer by combinatorial therapeutic modality based on chemotherapy and mild hyperthermia. The engineered iron oxide nanoparticle (IONPs)-based nanocarrier served as an efficient delivery vehicle for doxorubicin and provided the ability to heat cancer cells...
Resource Type:: Article
Full Text:: Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells Author: Olena Taratula Raj Kumar Dani Canan

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

Creator:: Taratula, Olena, Patel, Mehulkumar, Schumann, Canan, Naleway, Michael A., Pang, Addison J., He, Huixin, and Taratula, Oleh
Abstract:: We report a novel cancer-targeted nanomedicine platform for imaging and prospect for future treatment of unresected ovarian cancer tumors by intraoperative multimodal phototherapy. To develop the required theranostic system, novel low-oxygen graphene nanosheets were chemically modified with polypropylenimine dendrimers loaded with phthalocyanine (Pc) as a photosensitizer. Such a molecular design...
Resource Type:: Article
Full Text:: imaging-guided combinatorial phototherapy Taratula, O., Patel, M., Schumann, C., Naleway, M. A., Pang, A

Naphthalocyanine-Based Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy

Creator:: Taratula, Olena, Doddapaneni, Bhuvana S., Schumann, Canan, Li, Xiaoning, Bracha, Shay, Milovancev, Milan, Alani, Adam W. G., and Taratula, Oleh
Abstract:: Image-guided phototherapy is extensively considered as a promising therapy for cancer treatment. To enhance translational potential of this modality, we developed a single agent-based biocompatible nanoplatform that provides both real time near-infrared (NIR) fluorescence imaging and combinatorial phototherapy with dual photothermal and photodynamic therapeutic mechanisms. The developed theranostic nanoplatform consists...
Resource Type:: Article

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Creator:: Albarqi, Hassan Ahmad M.
Abstract:: Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
Resource Type:: Dissertation
Full Text:: Thanks to the lab mates, Leon H. Wong, Canan Schumann, Fahad Y. Sabei, Tetiana Korzun, Abraham S

Intraperitoneal Nanotherapy for Metastatic Ovarian Cancer Based on siRNA-Mediated Suppression of DJ-1 Protein Combined with a Low Dose of Cisplatin

Creator:: Schumann, Canan, Chan, Stephanie, Millar, Jess A., Bortnyak, Yuliya, Carey, Katherine, Fedchyk, Alex, Wong, Leon, Korzun, Tetiana, Moses, Abraham S., Lorenz, Anna, Shea, Delaney, Taratula, Olena, Khalimonchuk, Oleh, and Taratula, Oleh
Abstract:: Herein, we report an efficient combinatorial therapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin. DJ-1 protein modulates, either directly or indirectly, different oncogenic pathways that support and promote survival, growth, and invasion of ovarian cancer cells. To evaluate the...
Resource Type:: Article
Full Text:: Combined with a Low Dose of Cisplatin Canan Schumann, PharmDa,#, Stephanie Chana,#, Jess A. Millar, MSb

De novo synthesis of a sunscreen compound in vertebrates

Creator:: Osborn, Andrew R., Almabruk, Khaled H., Holzwarth, Garrett, Asamizu, Shumpei, LaDu, Jane, Kean, Kelsey M., Karplus, P. Andrew, Tanguay, Robert L., Bakalinsky, Alan T., and Mahmud, Taifo
Abstract:: Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought...
Resource Type:: Article
Full Text:: Floss on the occasion of his 80th birthday. The authors thank Canan Schumann, Oleh Taratula, Jun Ding

ScholarsArchive@OSU

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

Naphthalocyanine-Based Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Intraperitoneal Nanotherapy for Metastatic Ovarian Cancer Based on siRNA-Mediated Suppression of DJ-1 Protein Combined with a Low Dose of Cisplatin

De novo synthesis of a sunscreen compound in vertebrates

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