Index Catalog // ScholarsArchive@OSU

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Creator:: Kim, GilSoo
Abstract:: The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
Resource Type:: Dissertation
Full Text:: leuconoxine, and melodinine E and mersicarpine (Kim, R.; Ferreira, A.J.; Beaudry C. M. Angew. Chem. Int. Ed

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation
Full Text:: Christopher M. Beaudry Aromatic heterocycles are core structural motifs in natural products

Regioselective Synthesis of Substituted Phenols, Benzenes, Benzofuranones and Benzofurans and Synthesis of Homoharringtonine Analogs

Creator:: Zhang, Xiaojie
Abstract:: Substituted phenols are important substructures for pharmaceuticals, agrochemicals, natural products and biological probe molecules. The properties of phenolic molecules are substantially influenced by the substitution patterns of the phenolic ring. The chemical synthesis of phenols with various substitution patterns is an enduring challenge and multiple strategies have emerged. However, some...
Resource Type:: Dissertation

Learning to Teach Science from a Contextualized Stance

Creator:: L’Heureux, K., Giamellaro, M., Beaudry, M-C., Buxton, C., Ayotte-Beaudet, J-P., and Alajmi, T.
Abstract:: Contextualization is a curricular approach and a learning process in which science content knowledge is intentionally situated within a context where that knowledge can be authentically applied or observed. Many recent science education reforms include contextualization as a central tenet. Our goal in this review was to examine commonalities across...
Resource Type:: Conference Proceeding
Full Text:: Learning to Teach Science from a Contextualized Stance L’Heureux1, K., Giamellaro2*, M., Beaudry1, M-C

Stereocontrolled Synthesis of Allenes by Eliminative Cross-Coupling of Carbenoids

Creator:: Cao, Yang
Abstract:: The bimolecular reaction of two carbenoid species resulting in the formation of a carbon-carbon double bond (pi-system), referred to herein as carbenoid eliminative cross-coupling (CEXC), involves a series of three fundamental steps: (i) ate-complex formation (transmetalation), (ii) 1,2-metalate rearrangement, and (iii) beta-elimination. All three steps are stereospecific and so the...
Resource Type:: Dissertation
Full Text:: -chloroyinyl p-tolyl sulfoxide 62. This M X R3 R4 C R2 R3 R4 R2 R1 X’ M X R3 R4 -M’X’ M X R3 R4

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Creator:: Back, Daniel C.
Abstract:: Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
Resource Type:: Dissertation
Full Text:: )......................................................................................................................................... 97 Supplemental figure 2.42. Mass spectra of the [M-H]- ions of collimonin C (2.24) or collimonin

The preparation of common prebiotic oligosaccharides with defined degree of polymerization

Creator:: Ooi, Megan C. Y.
Abstract:: Prebiotics are a subset of dietary fiber that is growing in demand within the food industry. The health benefits of prebiotics have been well established, leading to the increase in its incorporation into various food products. Given the importance of prebiotics as functional ingredients, it is important to understand their...
Resource Type:: Masters Thesis
Full Text:: oligosaccharide with defined degree of polymerization Megan Ooi, XIaojie Zhang, Christopher M. Beaudry

The Preparation and Human Taste Detection of Maltooligosaccharides with Varying Degrees of Polymerization

Creator:: Andrewson, Toren S.
Abstract:: Starch is a significant component of the human diet and the glucose produced through its digestion provides a critical source of energy. When starch enters the mouth, salivary α-amylase hydrolyzes it into maltooligosaccharides (MOS, degree of polymerization [DP] 3-20) and maltopolysaccharides (MPS, DP >20). Previous studies have found that humans...
Resource Type:: Masters Thesis
Full Text:: from Michael H. Penner. Christopher M. Beaudry, Xiaojie Zhang, and Tucker Hamilton assisted with NMR

Development of Carbenoid Eliminative Cross-coupling for the Stereocontrolled Synthesis of Trisubstituted Alkenyl Moieties Within Styrenes and 1,3-Dienes

Creator:: Tanpure, Subhash D.
Abstract:: Traditional approaches for the direct preparation of alkenes are unable to fully control either the stereochemical configuration of the carbon-carbon double bond or else the regiochemistry of the substituents surrounding it. The recently introduced concept of carbenoid eliminative cross-coupling (CEXC) offers a remedy to these deficiencies by providing for a...
Resource Type:: Dissertation
Full Text:: )- HetNCH2CH2CH(OCb)Bneo (79) [HetN = 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, Cb = C(=O)Ni-Pr2, Bneo

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation
Full Text:: .; Han, L.-C.; Iqbal, Z.; Bailey, A. M.; Willis, C. L.; Simpson, T. J.; Cox, R. J. Nature

ScholarsArchive@OSU

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Regioselective Synthesis of Substituted Phenols, Benzenes, Benzofuranones and Benzofurans and Synthesis of Homoharringtonine Analogs

Learning to Teach Science from a Contextualized Stance

Stereocontrolled Synthesis of Allenes by Eliminative Cross-Coupling of Carbenoids

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

The preparation of common prebiotic oligosaccharides with defined degree of polymerization

The Preparation and Human Taste Detection of Maltooligosaccharides with Varying Degrees of Polymerization

Development of Carbenoid Eliminative Cross-coupling for the Stereocontrolled Synthesis of Trisubstituted Alkenyl Moieties Within Styrenes and 1,3-Dienes

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

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