Dihalocarbenes have been generated by thermal decomposition
of sodium trichloroacetate and tribromomethylphenylmercury, and
give mono dihalocyclopropyl adducts with steroid dienes. Such
compounds offer an easy starting point for the synthesis of unusual
derivatives of potential biological interest. Under the same conditions,
however, addition to non-conjugated double bonds does not
take...
In an attempt to find a laboratory species which develops an
experimental myopathy similar to white muscle disease (WMD) in
lambs, comparative studies of nutritional muscular dystrophy of
chicks were initiated. This condition was grossly visible as white
striations running parallel with the fibers of the pectoral muscles and
was...
Preparation of a cytochrome c-cytochrome oxidase complex
was achieved, using crystalline beef cytochrome c and purified
cytochrome oxidase from beef heart muscle, or from the
Keilin-Hartree preparation. Succinate oxidase was reconstituted
with the complex.
A mixture of cytochrome oxidase, solubilized with nonionic
detergent, and excess cytochrome c was exposed to...
White muscle disease or muscular dystrophy of sheep is a selenium
responsive malady common to many areas with an inherent natural
deficiency of selenium in the forage. The disease can be prevented in
lambs by adding trace amounts (approximately 0.1 ppm) of selenium to
the otherwise selenium deficient, forage fed...
In recent years nuclear reduction of pyrimidines by catalytic hydrogenation in acid media has been considered a possible synthetic method for the preparation of substituted tetrahydropyrimidines. This technique has the advantage of simplicity over the older condensation methods and is limited only by the preparation of the appropriately substituted pyrimidines....
The purpose of this project was to study the reactions of 1-(α-pyridyl)-3-buten-1-ol (compound I) and to determine whether or
not the products of some of its reactions are quinolizinium salts.
Reaction of compound I with bromine or iodine yields halide
salts (when no external cooling is applied) instead of the...
The ratio of the absolute infrared intensity, A₃/A₂, for the
parallel mode (2336 cm⁻¹) and the perpendicular mode (658 cm⁻¹)
of a nonpolar solute molecule, carbon dioxide, has been determined
in a nonpolar solvent, Nujol. The solution ratio (5.0) which has
been extrapolated to zero concentration is less than the...
The spectrophotometric method for the determination of the
acid nonextractable flavin in the proteolytic digest of the trichloroacetic
acid precipitate from the heart muscle preparation has been
examined for the interference of the degraded hemeproteins. The
proteolytic digest was chromatographically separated into the heme
and flavin fractions. Spectrophotometric determinations made...
Isocitrate-NADP oxidoreductase activity in mitochondrial and
soluble fractions was determined for hearts, livers and brains of
chick embryos at various stages of development. One-half to two-thirds
of the activity in brain and liver homogenates is located in the
soluble fraction. Supernatant activity increases in these organs to a
maximum during...
The mechanism of phosphate adsorption by clay minerals was
reported by Stout. He showed that the loss of water of kaolinite in
the presence of KC1, K₂SO₄ or KH₂PO₄ was due to an exchange reaction
between anion and hydroxyl groups from clay minerals. Also,
Kelly and Midgley reported that the...
Glucose-1, -2 and -6-C¹⁴ substrates were incorporated into
individual tomato fruits in order to study the catabolic fate of
substrate glucose, especially with regard to the possible occurrence
of triose recombination, as well as to investigate the pathways
leading to the biosynthesis of C₄ acids in the fruit. After metabolizing...
Quercetin (3, 3', 4', 5, 7-pentahydroxyflavone) reacts with hexavalent
molybdenum, tungsten and chromium to form chelates soluble
in an ethanol-water medium. This color reaction has been investigated
with a view to its possible application in the spectrophotometric
determination of trace amounts of these metals.
In the development of the method,...
The rate of the C¹⁴0₂ release from glucose, specifically labeled
with C¹⁴ at 1, 2, 3+4, and positions, was used to study the relative
participation of pathways of glucose catabolism in red beet slices.
Evidence was obtained which indicated that in mature red beets glucose
was catabolized mainly via glycolysis-tricarboxylic...
In 1959 Kitagawa discovered and isolated the amino acid,
canavanine. Since its discovery much interest has been centered on
this amino acid because of its biological aspects; e.g. canavanine has
been shown to inhibit the growth of bacteria, viruses, protozoa, and
cancer cells.
The occurrence of canavanine is widespread in...
A method of calculating the normal vibrations of polymer molecules
is presented in detail. The method is based on that used by
Schachtschneider and Snyder in their analysis of polypropylene but
has not heretofore been published. The factoring of the infinite matrix
and reduction to the coordinates of the unit...
The infrared absorption spectra in the out-of-plane
bending (v₂) region of potassium nitrate were studied for
three phases. Several types of sampled were used: nujol
mulls, fused samples, and N¹⁴-N¹⁵ isotopic mixtures. The
existence of three of the reported polymorphic phases was
confirmed by the spectra. The transitions between phase...
An
investigation was
made
into certain
aspects
of
protein
synthesis
at
different
developmental stages
of the
flesh fly
Sarcophaga
bullata.
This
included
measurements
of the
incorporation of
labeled
amino
acids into
protein
by intact cells
from
a
single
organ, the
larval
fat
body,
and
a
study
of
amino
acid
activating...
A large-scale preparative method for potassium di-n-butylborate
in triethylamine solvent has been developed. The reaction of
potassium di-n-butylborate I with trifluoromethyl iodide has been
shown to yield trifluoromethyl di-n-butylborane and other products.
Reaction of this substance with boron trifluoride gave trifluoromethyl
boron difluoride. Reactions of diboron tetrafluoride, boron tribromide,
and...