Index Catalog // ScholarsArchive@OSU

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation

Quantification of state-and-transition model components utilizing long-term ecological response data following one-seed juniper treatment on a deep sand savannah ecological site

Creator:: Shaver, Patrick L.
Abstract:: A proposed state-and-transition model (STM) for the Deep Sand Savannah ecological site in central New Mexico was developed using historical data and expert knowledge. This STM was tested utilizing data from short and long term one-seed juniper (Juniperus monosperma (Engelm.) Sarg.) control experiments initiated in 1981 and 1985. Utilizing data...
Resource Type:: Dissertation

Design techniques for low power ADCs

Creator:: Yu, Wenhuan
Abstract:: This dissertation presents an incremental analog-to-digital converter (ADC) with digital digital-to-analog converter (DAC) mismatch correction. A theoretical time-domain analysis technique was developed to predict the noise performance of the incremental ADC, and a new optimization technique was proposed to minimize the output noise. In the calibration mode, the incremental ADC...
Resource Type:: Dissertation

Low-power techniques for supply-noise mitigation in phase-locked loops

Creator:: Arakali, Abhijith
Abstract:: Modern day digital systems employ frequency synthesizers to provide a common clock to the system. They are undergoing large scale integration due to which, mitigation of the effect of noise on power supply has become a major design consideration in clocking circuits. Rapid scaling of CMOS technology mandates the design...
Resource Type:: Dissertation

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation

Studies toward the total synthesis of azaspiracid-1

Creator:: Kuiper, Damien L.
Abstract:: Azaspiracid has generated an enormous amount of scientific interest in the fourteen years since its initial discovery. The structure contains a 6,5,6 bis-spiroketal, a [3.3.1] bicyclic ketal and a 6,5-spiroaminal linkage as key moieties. With 9 rings, 20 stereocenters and three alkenes, the azaspiracid immediately attracted the interest of the...
Resource Type:: Dissertation

Limited magnitude error control codes

Creator:: Elarief, Noha
Abstract:: A relatively new model of error control is the limited magnitude error over high radix channels. In this error model, the error magnitude does not exceed a certain limit known beforehand. In this dissertation, we study systematic error control codes for common channels under the assumption that the maximum error...
Resource Type:: Dissertation

A macroscopic to microscopic study of the effects of barotrauma and the potential for long-term survival in Pacific rockfish

Creator:: Pribyl, Alena L.
Abstract:: Depleted species of rockfish (Sebastes spp.) from the Northeast Pacific experience high discard mortality due to "barotrauma," induced from the rapid change in pressure during capture. Research suggests rockfish have the potential to survive barotrauma if immediately recompressed, but the potential for long-term recovery is unknown. In this project, we...
Resource Type:: Dissertation

Magnetic particles for selective extraction of trace analytes in microfluidic devices

Creator:: Tennico, Yolanda H.
Abstract:: The development of micro total analysis systems (µTAS), also called “lab-on-a-chip”, or microfluidic analysis systems, is presented in this dissertation. Various research areas, covering subjects from magnetic particles synthesis to novel microchip fabrication techniques, are explored to develop a lab-on-a-chip system capable of performing magnetic bead-based bioassays. These devices are...
Resource Type:: Dissertation

Biogeography of nonindigenous species: from description to prediction

Creator:: Reusser, Deborah A.
Abstract:: Nonindigenous species are a major threat to the ecological integrity and biodiversity of marine and estuarine ecosystems. To become a successful invader, species must pass through four phases: (1) survive transport, (2) survive release, (3) establish a population, and (4) expand their range. To better understand these processes, an integrated...
Resource Type:: Dissertation

ScholarsArchive@OSU

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Quantification of state-and-transition model components utilizing long-term ecological response data following one-seed juniper treatment on a deep sand savannah ecological site

Design techniques for low power ADCs

Low-power techniques for supply-noise mitigation in phase-locked loops

The study of pharmacokinetics in a clinical environment

Studies toward the total synthesis of azaspiracid-1

Limited magnitude error control codes

A macroscopic to microscopic study of the effects of barotrauma and the potential for long-term survival in Pacific rockfish

Magnetic particles for selective extraction of trace analytes in microfluidic devices

Biogeography of nonindigenous species: from description to prediction

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