A study was designed to examine the pharmacokinetics of theophylline in a well defined group of congestive heart failure (CHF) patients, without liver disease, and to evaluate the validity of the dosage guidelines recommended by the FDA. A total of five CHF patients and seven non-CHF patients were entered and...
The positions of the DNase I hypersensitive sites within the
galactose gene cluster of the yeast Saccharomyces cerevisiaa have
been determined. When yeast nuclei were incubated with DNase I, the
purified DNA restriction endonuclease digested and analyzed by
Southern hybridization, five hypersensitive regions were observed in
this cluster of three...
The tosylhydrazones of 2-heptanone, 4,4-dimethy1-2-
heptanone, 6-heptyn-2-one and 4,4-dimethy1-6-heptyn-2-
one were synthesized and decomposed under a variety of
reaction conditions: dry lithium and sodium salt pyrolyses,
sodium methoxide thermolyses in diglyme and photolyses of
the lithium salt in tetrahydrofuran. The saturated analogues
2-heptanone tosylhydrazone and its 4,4-dimethyl
isomer afforded the...
The role of the yeast S-adenosylmethionine: Δ²⁴-sterol-C-methyltransferase
(SCMT) in sterol metabolism was investigated.
Structural analogs of S-adenosylhomocysteine were tested for
inhibition of the SCMT enzyme. A wide inhibitory range by these
compounds was observed, indicating which structural features of the
parent compound are important for binding to the enzyme. The...
Studies were conducted to determine the effects of cyclopropenoid
fatty acids (CPFA) on the microsomal membrane of livers of rainbow
trout (Salmo gairdneri). Slab and tube gel electrophoresis of
microsomes from trout fed a CPFA diet (CPFA-microsomes) for varying
time periods showed a decrease in the number of protein bands...
The bioavailability of niacin from tuna fish, peanut butter
and whole wheat bread was estimated in eight men aged 21 to 30 years.
Following a 10-day adjustment period, each test food, which was added
to a constant basal diet, was fed for 14 days; the order in which
these three...
The U.S. white wheat industry relies heavily on export markets.
Since the early 1960s these markets have been geographically concentrated
in a few countries in Asia. This suggests that developments
in a few Asian countries may significantly affect the prospects for
U.S. white wheat exports and thereby the economic well...
The Russell Ranch oil field is located in the southern Coast
Ranges west of Bakersfield, California. Detailed subsurface
mapping shows that a northwest-oriented right-lateral wrench-fault
system was active from possibly latest Oligocene to Pliocene time.
The effects of Quaternary thrusting were superimposed on, and influenced
by, structures associated with the...