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Filtering by: Date issued sim 1990-04-13 Remove constraint Date issued sim: 1990-04-13 Degree Level Doctoral Remove constraint Degree Level: Doctoral

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  • Studies of the biosynthesis of Sarubicin A

    Creator:
    Eisenberg, Rodney L.
    Abstract:
    Early studies on the biosynthesis of Sarubicin A, 1, had suggested the intermediacy of the novel aromatic amino acid 6-hydroxyanthranilic acid, 17. To investigate the biosynthetic steps beyond 17, [¹³C-¹⁵N carboxamide] 6-hydroxyanthranilamide, 27a, was synthesized, and fed to fermentations of Streptomyces helicus. Incorporation of 27a into 1 provided suggestive evidence...
    Resource Type:
    Dissertation