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Filtering by: Date issued sim 1991-04-30 Degree Name Doctor of Philosophy (Ph.D.)

Structural and functional dissection of the vaccinia virus thymidine kinase enzyme

Creator:

Black, Margaret E.

Abstract:

Thymidine kinase is a key enzyme in the nucleotide salvage pathway, catalyzing the production of dTMP from thymidine and ATP. In order to identify the structural features of the TK protein and/or primary amino acid sequences which contribute to the catalytic and regulatory activities of this enzyme, an in vitro...

Resource Type:

Dissertation
Sequence conversion during adenovirus DNA replication

Creator:

Bennett, Kelly L.

Abstract:

The work in this thesis has provided conclusive genetic evidence that "panhandle" intermediates form during adenovirus replication. Adenovirus chromosomes lacking 51 by from their left -hand termini are infectious and capable of regenerating the missing origin sequence. Yet if an entire inverted terminal repeat is removed, the adenovirus chromosome is...

Resource Type:

Dissertation
A nonlinear shallow water wave equation and its classical solutions of the cauchy problem

Creator:

Crow, John A.

Abstract:

A nonlinear wave equation is developed, modeling the evolution in time of shallow water waves over a variable topography. As the usual assumptions of a perfect fluid and an irrotational flow are not made, the resulting model equation is dissipative due to the presence of a viscous boundary layer at...

Resource Type:

Dissertation