The three dimensional structure of both a ligand and its cognate receptor are required for the success of structure-assisted drug design. This thesis reports the crystal structure of hectochlorin, a small, bioactive molecule, and the steps toward determining the crystal structure of an RNA molecule that is an attractive target...
The spruce weevil (Pissodes strobi) is a serious pest of Sitka spruce in Oregon. Weevils cause damage by killing the leader of a tree, resulting in defects such as crooks and forks that can render the tree unmerchantable. In this study, spruce stands 16-25 years old were surveyed for weevil...